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. 1979 Dec;76(12):6120–6123. doi: 10.1073/pnas.76.12.6120

Action of cathepsin D on human beta-lipotropin: a possible source of human "beta-melanotropin".

E Barát, A Patthy, L Gráf
PMCID: PMC411814  PMID: 293708

Abstract

Highly purified calf brain cathepsin D (EC 3.4.23.5) selectively splits the Leu77-Phe78 and Ala36-Ala37 peptide bonds of human beta-lipotropin. It is suggested that the formation of human "beta-melanotropin" from gamma-lipotropin, and that of gamma-endorphin from beta-endorphin, is due to the action of cathepsin D during isolation procedures.

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Selected References

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