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. 1979 Dec;76(12):6124–6127. doi: 10.1073/pnas.76.12.6124

Semisynthesis of human somatotropin analogs.

C H Li, J Blake
PMCID: PMC411815  PMID: 293709

Abstract

Complementation of the natural NH2-terminal 134-amino acid fragment of the reduced, carbamoylmethylated human somatotropin with synthetic analogs of COOH-terminal fragments of 57, 42, or 38 amino acids of reduced, carbamoyl-methylated human somatotropin has been investigated. It was found that synthetic fragments of 57 and 42 amino acids gave recombinants with full growth-promoting activity, whereas attempts to obtain a recombinant with the synthetic 38-amino acid fragment were unsuccessful. The synthesis of two analogs of the COOH-terminal fragment of human somatotropin, human [N]e170, Ala165,182,189] somatotropin-(150-191) and human [Nle170, Ala165,182,189] somatotropin-(154-191), is herein described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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