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. 1979 Dec;76(12):6591–6595. doi: 10.1073/pnas.76.12.6591

Impairment of antigen-presenting cell function by ultraviolet radiation.

M I Greene, M S Sy, M Kripke, B Benacerraf
PMCID: PMC411912  PMID: 160568

Abstract

UV light irradiation of BALB/c mice was found to result in impairment of antigen-presenting cell function. Adherent trinitrophenyl-derivatized cells from the peritoneal exudate cell population or the spleen of UV-treated donors could not induce hapten-specific delayed hypersensitivity responses in UV-irradiated syngeneic mice, whereas adherent trinitrophenyl-derivatized cells from normal mice were able to do so. The failure to induce immunity in UV-treated mice by utilizing UV-treated adherent antigen-presenting cells was associated with the development of antigen-specific suppressor T cells. The implication of these results for UV-induced carcinogenesis is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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