Isaac T. Yonemoto†, Wei Li†, Ankush Khullar†, Natàlia Reixach‡, Barbara Gerratana*†
†Department of Chemistry and Biochemistry, College of Computer, Mathematical and Natural Sciences, University of Maryland, College Park, Maryland, 20472
‡Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla California 92037, United States
* bgerratana@hotmail.com
This correction is issued with respect to the DNA melting point assay in our article “Mutasynthesis of a Potent Anticancer Sibiromycin Analogue” (ACS Chem. Biol. 2012, 7, 973–977; DOI: 10.1021/cb200544u). Specifically, on page 976 in the Methods section, we state “DNA:PBD = 1:20” was used in the DNA melting point assay, which is incorrect. The correct representation is likely “DNA:PBD = 20:1”, but requires confirmation with further experimentation. Consequently, we withdraw the Tm measurements described in the second paragraph of page 974 and the conclusion that deoxysibiromycin binds more tightly to DNA than sibiromycin. Future experiments repeating the melting point assay will be admitted into the scientific record. This correction does not change any other aspects in the interpretation of data, analysis, or the article’s conclusions. The authors apologize for this unintended error.