Figure 1. The schematic diagram of our analysis. We combined DNA methylation and gene expression data in breast cancer samples from TCGA, and TF binding and DNase I hypersensitivity data from ENCODE. We identified the CpG sites with differential methylation levels between ER+ and ER- breast cancer samples, and examined the correlation of their methylation levels with expression of associated genes. Blue double arrows denote comparative analysis of regions of interest to outside regions.