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Physical properties of D-gal induced aging skin wound after each treatment. (a) Epidermal thickness (μm), (b) dermal thickness (μm), (c) collagen fiber density (mm2), (d) water content (%), (e) hydroxyproline content (μg/mg protein). ∗, †, $, Ψ, Σ, and ® denote a significant difference (P < 0.05) relative to negative control, sham control, NS, AA, 0.1% DMAE, and 0.2% DMAE, respectively. For water content assay, no significant difference existed among all treatment groups.
