Fig. 6.
XNC10-deficient tumors elicit, and are rejected by, cell-mediated cytotoxic responses. 5×105 cells at a 1:1 ratio of WT-PKH/WT-CFSE or WT-PKH/shXNC10 #7-CFSE were injected into LG-15 tadpoles. (A) Representative flow cytometry plots of cells harvested from individual tadpoles at 2, 4 and 7 days posttransplantation. (B) Calculated percent rejection from individual tadpoles of WT-CFSE and shXNC10#7-CFSE tumors 2, 4 and 7 days posttransplantation. (C) Number of WT-CFSE and shXNC10#7-CFSE cells injected (day 0) and retrieved from individual tadpoles at 2, 4 and 7 days posttransplantation. One representative experiment shown where n = 6–8 animals.