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. Author manuscript; available in PMC: 2014 Aug 11.
Published in final edited form as: Glia. 2013 Aug 5;61(10):1687–1697. doi: 10.1002/glia.22549

FIGURE 7.

FIGURE 7

Signaling pathways that regulate Müller glial-derived regeneration of retinal neurons. Signaling pathways implicated in Müller glial response to retinal injury and retinal regeneration based on the present work and published studies (Bernardos et al., 2005; Ikeda and Puro, 1995; Inbal et al., 2007; Liu et al., 2006; Liu et al., 2011; Meyers et al., 2012; Nelson et al., 2012, 2013; Ramachandran et al., 2010; Robel et al., 2011; Thummel et al., 2010; Wan et al., 2012). Regeneration requires a dynamically balanced regulation of signals and transcriptional regulators promoting proliferation and differentiation, as well as cell fate choices between a glial fate (gliosis) and a neuronal fate (neurogenesis). See text for details.