Table 1.
Biological pathways associated with targets of miRNAs differentially expressed in hantavirus infection. Differential expression of miRNAs during hantavirus infection was subjected to target prediction and pathway enrichment analyses. All pathways were obtained from the KEGG and target analysis was performed using Tarbase, TargetScan, miRanda, microRNA.org and microcosm.
| miRNA | Integrin signaling pathway |
Chemokine signaling pathway |
RIG-I-like receptor signaling pathway |
NOD-like receptor signaling pathway |
Toll-like receptor signaling pathway |
Jak-STAT signaling pathway |
PI3K-Akt signaling pathway | VEGF signaling pathway |
MAPK signaling pathway |
|---|---|---|---|---|---|---|---|---|---|
| miR-494 | FZD3, DNAJC, MYNN, APLN | STAT1, GNG10, RAP1B, PAK1, IKBKB, MAP2K1 | IKBKB, IL12B | IKBKB | IKBKB, IL12B, STAT1, MAP2K1, TLR6 | IL12B, STAT1, IL6ST, IL5RA, STAM, IL26, SOCS5, SOCS4, MYC | IKBKB, GNG10, MAP2K1, FGFR2, CDK6, CDK4, MYC, IGF1R | MAP2K1, PTGS2 | IKBKB, RAP1B, PAK1, MAP2K1, FGFR2, IL1R1, PPM1A, MAP4K4, IL1A, JUND, MYC, STK3 |
| miR-1225-5p | NR1H4 | IFNG | |||||||
| miR-642-3p | ASB2, C12orf4 | CYLD, CASP10 | MAP2K6 | CBL, IL11 | FLT1, LPAR4, SYK, ANGPT1, ITGB8 | PPM1A, PAK2, MAP2K6 | |||
| miR-151a-5p | NTRK2 | ||||||||
| miR-29c-3p | PCDHA10, YPEL2 | CDC42 | DDX3X | IGF1, SGK1, CDK2, LAMC1 | CDC42 | CDC42 | |||
| miR-1973 | IL8 | IL8 | IL8 | IL8 | CACNB1 | ||||
| miR-210 | CACNA1C | ||||||||
| miR-3656 | PXN | PXN | |||||||
| miR-1915-3p | KCNC1, | ADCY1, FOXO3, | MAVS, IKBKE | IKBKE, IRAK1, | SOCS7, PTPN6, | FOXO3, GSK3B, PDGFRB, BCL2, FLT4, SYK, | SRF, PDGFRB, CACNG2, CACNG1, FGFR3 | ||
| VAMP1 | GSK3B | MYD88 | IL20RB, IL2RB | IL2RB, FGFR3 | |||||
| miR-1268a | TOLLIP | ||||||||
| miR-199a-5p | ATP9A, ZNF563 | GSK3B | DDX3X | IL13 | GSK3B, CDKN1B | TGFB2, MAP3K11, STK4 | |||
| miR-193a-3p | ST6GALNAC3, PLAU | OSMR | OSMR, MCL1, LAMC2 | STMN1, CACNA1E, NF1 | |||||
| miR-1207-5p | 41531, SBNO1 | CX3CL1, SRC | CASP10 | RIPK2 | MAP2K6, TLR6 | STAT6, CBL, IL6ST | CHAD, CSF1, LAMC3, FLT1, CHRM1, PDPK1, ITGB3 | SRC, MAPKAPK2 | MAPKAPK2, CACNA2D1, MAP2K6, JUND, TGFBR2, TGFBR1, CACNG7, PPM1B, CACNB3, RAPGEF2, MAPK8IP3 |
| miR-222-3p | CBWD2, MEGF9 | JAK3 | CYLD, AZI2 | FOS | JAK3, PRLR | JAK3, KIT, CDKN1B, KDR, MDM2, PRLR | KDR | NTF3, CACNB4, NLK, STMN1, FOS | |
| miR-181b-5p | SPP1, ITGA2, ITGB8, GP5 | KRAS, RAP1B, NRAS, GNB4, MAP2K1 | DDX3X, ATG5 | CARD8 | MAP2K1, SPP1, TLR4, MAP2K4, MAP3K8, IRF5 | IL2, LIFR, CSF2RB, PRLR, SOCS4 | KRAS, NRAS, GNB4, MAP2K1, CREB1, SPP1, ITGA2, IL2, CREB5, PRLR, FLT1, PDGFRA, KITLG, TLR4, ITGB8, SGK3, DDIT4 | KRAS, N RAS, MAP2K1, PTGS2 | KRAS, RAP1B, NRAS, MAP2K1, TGFBR1, PDGFRA, IL1A, ZAK, MAP2K4, GNA12, MAP3K8, CACNA2D4, MAP3K3 |