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. Author manuscript; available in PMC: 2014 Aug 12.
Published in final edited form as: Virology. 2013 Sep 2;446(0):217–224. doi: 10.1016/j.virol.2013.07.036

Table 1.

Biological pathways associated with targets of miRNAs differentially expressed in hantavirus infection. Differential expression of miRNAs during hantavirus infection was subjected to target prediction and pathway enrichment analyses. All pathways were obtained from the KEGG and target analysis was performed using Tarbase, TargetScan, miRanda, microRNA.org and microcosm.

miRNA Integrin
signaling
pathway
Chemokine
signaling
pathway
RIG-I-like
receptor
signaling
pathway
NOD-like
receptor
signaling
pathway
Toll-like
receptor
signaling
pathway
Jak-STAT signaling
pathway
PI3K-Akt signaling pathway VEGF
signaling
pathway
MAPK signaling pathway
miR-494 FZD3, DNAJC, MYNN, APLN STAT1, GNG10, RAP1B, PAK1, IKBKB, MAP2K1 IKBKB, IL12B IKBKB IKBKB, IL12B, STAT1, MAP2K1, TLR6 IL12B, STAT1, IL6ST, IL5RA, STAM, IL26, SOCS5, SOCS4, MYC IKBKB, GNG10, MAP2K1, FGFR2, CDK6, CDK4, MYC, IGF1R MAP2K1, PTGS2 IKBKB, RAP1B, PAK1, MAP2K1, FGFR2, IL1R1, PPM1A, MAP4K4, IL1A, JUND, MYC, STK3
miR-1225-5p NR1H4 IFNG
miR-642-3p ASB2, C12orf4 CYLD, CASP10 MAP2K6 CBL, IL11 FLT1, LPAR4, SYK, ANGPT1, ITGB8 PPM1A, PAK2, MAP2K6
miR-151a-5p NTRK2
miR-29c-3p PCDHA10, YPEL2 CDC42 DDX3X IGF1, SGK1, CDK2, LAMC1 CDC42 CDC42
miR-1973 IL8 IL8 IL8 IL8 CACNB1
miR-210 CACNA1C
miR-3656 PXN PXN
miR-1915-3p KCNC1, ADCY1, FOXO3, MAVS, IKBKE IKBKE, IRAK1, SOCS7, PTPN6, FOXO3, GSK3B, PDGFRB, BCL2, FLT4, SYK, SRF, PDGFRB, CACNG2, CACNG1, FGFR3
VAMP1 GSK3B MYD88 IL20RB, IL2RB IL2RB, FGFR3
miR-1268a TOLLIP
miR-199a-5p ATP9A, ZNF563 GSK3B DDX3X IL13 GSK3B, CDKN1B TGFB2, MAP3K11, STK4
miR-193a-3p ST6GALNAC3, PLAU OSMR OSMR, MCL1, LAMC2 STMN1, CACNA1E, NF1
miR-1207-5p 41531, SBNO1 CX3CL1, SRC CASP10 RIPK2 MAP2K6, TLR6 STAT6, CBL, IL6ST CHAD, CSF1, LAMC3, FLT1, CHRM1, PDPK1, ITGB3 SRC, MAPKAPK2 MAPKAPK2, CACNA2D1, MAP2K6, JUND, TGFBR2, TGFBR1, CACNG7, PPM1B, CACNB3, RAPGEF2, MAPK8IP3
miR-222-3p CBWD2, MEGF9 JAK3 CYLD, AZI2 FOS JAK3, PRLR JAK3, KIT, CDKN1B, KDR, MDM2, PRLR KDR NTF3, CACNB4, NLK, STMN1, FOS
miR-181b-5p SPP1, ITGA2, ITGB8, GP5 KRAS, RAP1B, NRAS, GNB4, MAP2K1 DDX3X, ATG5 CARD8 MAP2K1, SPP1, TLR4, MAP2K4, MAP3K8, IRF5 IL2, LIFR, CSF2RB, PRLR, SOCS4 KRAS, NRAS, GNB4, MAP2K1, CREB1, SPP1, ITGA2, IL2, CREB5, PRLR, FLT1, PDGFRA, KITLG, TLR4, ITGB8, SGK3, DDIT4 KRAS, N RAS, MAP2K1, PTGS2 KRAS, RAP1B, NRAS, MAP2K1, TGFBR1, PDGFRA, IL1A, ZAK, MAP2K4, GNA12, MAP3K8, CACNA2D4, MAP3K3