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Rac1-ERK pathway was required for the radixin-mediated MMP-7 production. (a) and (b) After knockdown of radixin by siRNA, the production of MMP-7 was observed by real-time PCR and ELISA assay. (c) and (d) After incubation with NSC23766 or DMSO for 12 h, MMP-7 production was determined by real-time PCR and ELISA assay. (e) and (f) After incubation with U0126 or DMSO for 12 h, MMP-7 production was detected by real-time PCR and ELISA assay. *P < 0.05.
