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. 1979 Oct;76(10):5277–5281. doi: 10.1073/pnas.76.10.5277

Involvement of gangliosides in lymphocyte stimulation.

S Spiegel, A Ravid, M Wilchek
PMCID: PMC413124  PMID: 116227

Abstract

N4-Dinitrophenyl-L-2,4-diaminobutyric acid hydrazide was attached covalently to the aldehyde groups produced by periodate oxidate of bovine brain gangliosides and it was incorporated into mature thymocytes. High concentrations of antibodies to dinitrophenyl (DNP) or lower concentrations followed by protein A agglutinated the cells and stimulated DNA synthesis. Incubation of the thymocytes containing DNP-modified ganglioside with rabbit anti-DNP and fluorescein-labeled anti-rabbit IgG resulted in the formation of uniform rings on the cell surface, which subsequently developed into patches and caps. These results indicate that gangliosides may play a primary role in the lymphocyte activation process.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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