Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1979 Oct;76(10):5294–5298. doi: 10.1073/pnas.76.10.5294

Tumor-enhancing suppressor activator T cells in spleens and thymuses of tumor immune mice.

I Hellström, K E Hellström, I D Bernstein
PMCID: PMC413128  PMID: 315560

Abstract

Cells from the spleens and thymuses of BALB/c mice whose Moloney sarcoma virus (MSV)-induced, primary sarcomas have regressed 2-3 months earlier ("MSV regressors") or are in the process of regressing can, when adoptively transferred to syngeneic mice given MSV at the age of 20 days, prevent the natural regression of the MSV sarcomas in the recipient mice. The cells responsible for this tumor-enhancing effect express the Thy 1 marker. They are not demonstrable in the thymuses of normal untreated mice or in mice that have either been immunized against or are bearing methylcholanthrene-induced sarcomas. The tumor-enhancing cells are not destroyed after administration of 400 rads (1 rad = 1.00 x 10(-2) J/kg) of whole body radiation. However, the effect of the irradiated cells is seen only in the presence of a nonirradiated T-cell population, represented in the thymuses of normal control mice, with which we postulate that they interact. Studies on a transplantable, chemically induced, murine leukemia virus antigen-negative sarcoma, MCA-1460, further support the concept that relatively radioresistant thymus cells from immune mice can enhance tumor outgrowth by interacting with radiosensitive T cells that are present in nonimmune mice.

Full text

PDF
5294

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown J. P., Klitzman J. M., Hellström I., Nowinski R. C., Hellström K. E. Antibody response of mice to chemically induced tumors. Proc Natl Acad Sci U S A. 1978 Feb;75(2):955–958. doi: 10.1073/pnas.75.2.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cantor H., Gershon R. K. Immunological circuits: cellular composition. Fed Proc. 1979 Jun;38(7):2058–2064. [PubMed] [Google Scholar]
  3. Fefer A., McCoy J. L., Glynn J. P. Antigenicity of a virus-induced murine sarcoma (Moloney). Cancer Res. 1967 May;27(5):962–967. [PubMed] [Google Scholar]
  4. Gershon R. K., Mokyr M. B., Mitchell M. S. Activation of suppressor T cells by tumour cells and specific antibody. Nature. 1974 Aug 16;250(467):594–596. doi: 10.1038/250594a0. [DOI] [PubMed] [Google Scholar]
  5. Greene M. I., Dorf M. E., Pierres M., Benacerraf B. Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum. Proc Natl Acad Sci U S A. 1977 Nov;74(11):5118–5121. doi: 10.1073/pnas.74.11.5118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hellström K. E., Hellström I. Evidence that tumor antigens enhance tumor growth in vivo by interacting with a radiosensitive (suppressor?) cell population. Proc Natl Acad Sci U S A. 1978 Jan;75(1):436–440. doi: 10.1073/pnas.75.1.436. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hellström K. E., Hellström I., Kant J. A., Tamerius J. D. Regression and inhibition of sarcoma growth by interference with a radiosensitive T-cell population. J Exp Med. 1978 Sep 1;148(3):799–804. doi: 10.1084/jem.148.3.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hellström K. E., Hellström I., Nepom J. T. Specific blocking factors--are they important? Biochim Biophys Acta. 1977 Dec 23;473(2):121–148. doi: 10.1016/0304-419x(77)90003-8. [DOI] [PubMed] [Google Scholar]
  9. Kiessling R., Petranyi G., Kärre K., Jondal M., Tracey D., Wigzell H. Killer cells: a functional comparison between natural, immune T-cell and antibody-dependent in vitro systems. J Exp Med. 1976 Apr 1;143(4):772–780. doi: 10.1084/jem.143.4.772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nelson K., Pollack S. B., Hellström K. E. Specific anti-tumor responses by cultured immune spleen cells. I. In vitro culture method and initial characterization of factors which block immune cell-mediated cytotoxicity in vitro. Int J Cancer. 1975 May 15;15(5):806–814. doi: 10.1002/ijc.2910150512. [DOI] [PubMed] [Google Scholar]
  11. Prehn R. T., Lappé M. A. An immunostimulation theory of tumor development. Transplant Rev. 1971;7:26–54. doi: 10.1111/j.1600-065x.1971.tb00462.x. [DOI] [PubMed] [Google Scholar]
  12. Rao V. S., Bennett J. A., Grodzicki R. L., Mitchell M. S. Suppressor T cells induced by soluble immune complexes can adoptively transfer inhibition of cytophilic antibody receptors on macrophages. Cell Immunol. 1979 Sep 1;46(2):227–238. doi: 10.1016/0008-8749(79)90412-x. [DOI] [PubMed] [Google Scholar]
  13. Reinisch C. L., Andrew S. L., Schlossman S. F. Suppressor cell regulation of immune response to tumors: abrogation by adult thymectomy. Proc Natl Acad Sci U S A. 1977 Jul;74(7):2989–2992. doi: 10.1073/pnas.74.7.2989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Röllinghoff M., Starzinski-Powitz A., Pfizenmaier K., Wagner H. Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes. J Exp Med. 1977 Feb 1;145(2):455–459. doi: 10.1084/jem.145.2.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tamerius J. D., Hellström I. In vitro demonstration of complement-dependent cytotoxic antibodies to Moloney sarcoma cells. J Immunol. 1974 Jun;112(6):1987–1996. [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES