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. 1979 Oct;76(10):5308–5312. doi: 10.1073/pnas.76.10.5308

Electrophoretically pure mouse interferon exerts multiple biologic effects.

I Gresser, J De Maeyer-Guignard, M G Tovey, E De Maeyer
PMCID: PMC413131  PMID: 291948

Abstract

Electrophoretically pure mouse interferon was examined for a number of biologic effects previously ascribed to crude or partially purified interferon preparations. These effects include: inhibition of the growth of a transplantable tumor in mice; inhibition of cell multiplication of mouse tumor cells in vitro; enhancement of the expression of histocompatibility antigens on mouse tumor cells in vitro; inhibition of antibody formation in vitro; inhibition of sensitization to sheep erythrocytes and the expression of delayed type hypersensitivity in mice; enhancement of natural killer cell activity in vivo and in vitro; enhancement of cell sensitivity to the toxicity of poly(I)-poly(C); and enhanced production ("priming") of interferon production in vitro. Our results establish that the molecules responsible for the antiviral action of interferon are also responsible for these varied biologic effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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