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. 2013 Nov 27;3(6):277–281. doi: 10.1007/s13659-013-0073-0

New amide alkaloids from Piper longum fruits

Jun Yang 1, Yao Su 1,2, Ji-Feng Luo 1, Wei Gu 1, Hong-Mei Niu 1, Yan Li 3, Yue-Hu Wang 1,✉, Chun-Lin Long 1,4,✉
PMCID: PMC4131601

Abstract

Three new amide alkaloids piperlongumamides A-C (1–3), together with 12 known ones (4–15), were isolated from the fruits of Piper longum. The structures of the new isolates were determined using spectroscopic data analyses. Cytotoxic activity of these amides against HL-60 (human leukemia), A-549 (human lung cancer), MCF-7 (human breast cancer), SMMC-7721 (human liver cancer) and SW480 (human rectal cancer) cell lines were evaluated. Piperchabamide B (11) exhibited weak inhibitory activity against HL-60 (IC50 = 21.32 μM ), A-549 (IC50 = 23.82 μM ) and MCF-7 (IC50 = 16.58 μM ) cell lines. graphic file with name 13659_2013_73_Article_Fig1_HTML.jpg

Electronic Supplementary Material

Supplementary material is available for this article at 10.1007/s13659-013-0073-0 and is accessible for authorized users.

Keywords: Piperaceae, Piper longum, amide alkaloids, piperlongumamides, piperchabamide B, cytotoxicity

Electronic supplementary material

13659_2013_73_MOESM1_ESM.pdf (2MB, pdf)

Supplementary material, approximately 1.95 MB.

Footnotes

This article is published with open access at Springerlink.com

Contributor Information

Yue-Hu Wang, Email: wangyuehu@mail.kib.ac.cn.

Chun-Lin Long, Email: long@mail.kib.ac.cn.

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Supplementary Materials

13659_2013_73_MOESM1_ESM.pdf (2MB, pdf)

Supplementary material, approximately 1.95 MB.

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