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. 2011 Dec 12;1(3):116–120. doi: 10.1007/s13659-011-0031-7

Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

Rui Zhan 1,2, Xue Du 1, Jia Su 1, Xiao-Nian Li 1, Wei-Guang Wang 1, Cheng-Qin Liang 1, Jian-Hong Yang 1, Yan Li 1, Jian-Xin Pu 1,✉, Han-Dong Sun 1,✉
PMCID: PMC4131646

Abstract

Three new ent-kauranoids, isorosthornins A-C (1–3), and a new natural product, dihydroponicidin (4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines. Inline graphic

Electronic Supplementary Material

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Keywords: Isodon rosthornii, ent-kaurane diterpenoid, cytotoxicity

Electronic supplementary material

13659_2011_31_MOESM1_ESM.pdf (590.5KB, pdf)

Supplementary material, approximately 590 KB.

Footnotes

This article is published with open access at Springerlink.com

Contributor Information

Jian-Xin Pu, Email: pujianxin@mail.kib.ac.cn.

Han-Dong Sun, Email: hdsun@mail.kib.ac.cn.

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Supplementary Materials

13659_2011_31_MOESM1_ESM.pdf (590.5KB, pdf)

Supplementary material, approximately 590 KB.

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