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. 2011 Sep 27;1(2):75–80. doi: 10.1007/s13659-011-0011-y

Chemical investigation on the cultures of the fungus Xylaria carpophila

Xia Yin 1,2, Tao Feng 1, Zheng-Hui Li 1, Jia Su 1, Yan Li 1, Ning-Hua Tan 1, Ji-Kai Liu 1,✉
PMCID: PMC4131652

Abstract

A chemical investigation on the cultures of Xylaria carpophila led to the isolation of one known cyclopeptide cyclo(Nmethyl-l-Phe-l-Pro-l-Leu-d-Ile-l-Val) (1), five new sesquiterpenes, named as xylcarpins A–E (2–6), and another known compound (7). The structures were determined by extensive NMR and MS spectroscopic analysis. The absolute configuration of 1 was established by use of Marfey’s method and ROESY spectroscopic data. All compounds were tested for their cytotoxicities against five human cancer cell lines. Compound 7 showed week inhibitory activity.graphic file with name 13659_2011_11_Article_Fig1_HTML.jpg

Electronic Supplementary Material

Supplementary material is available for this article at 10.1007/s13659-011-0011-y and is accessible for authorized users.

Keywords: Xylaria carpophila, sesquiterpenes, cyclopeptide, cytotoxicity

Electronic supplementary material

13659_2011_11_MOESM1_ESM.pdf (2.4MB, pdf)

Supplementary material, approximately 2.39 MB.

Footnotes

This article is published with open access at Springerlink.com

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Supplementary Materials

13659_2011_11_MOESM1_ESM.pdf (2.4MB, pdf)

Supplementary material, approximately 2.39 MB.

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