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. 2013 Mar 7;3(2):70–73. doi: 10.1007/s13659-012-0103-3

Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

Cheng-Bo Li 1103, Cong Wang 1103,2103, Wei-Wei Fan 1103,2103, Fa-Wu Dong 1103,2103, Feng-Qing Xu 1103,2103, Qin-Li Wan 1103, Huai-Rong Luo 1103, Yu-Qing Liu 1103, Jiang-Miao Hu 1103,, Jun Zhou 1103
PMCID: PMC4131658

Abstract

15 compounds, including two new ones crepidatuols A (1) and B (2) were isolated from the stems of Dendrobium crepidatum. The planar structures of these compounds were elucidated by spectroscopic methods (NMR, MS, UV, and IR) and comparison with those from literatures. 10 compounds were send for enhancing activities on nerve growth factor (NGF) medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A (1), confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol showed enhancing activities at the concentration of 10.0 µM. graphic file with name 13659_2012_103_Article_Fig1_HTML.jpg

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Keywords: Orchidaceae, Dendrobium crepidatum, bibenzyl, neurite outgrowth enhancing activity

Electronic supplementary material

13659_2012_103_MOESM1_ESM.pdf (3.3MB, pdf)

Supplementary material, approximately 3.25 MB.

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Supplementary Materials

13659_2012_103_MOESM1_ESM.pdf (3.3MB, pdf)

Supplementary material, approximately 3.25 MB.


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