New jatropholane-type diterpenes from Jatropha curcas cv. Multiflorum CY Yang

Yuan-Feng Yang; Jie-Qing Liu; Lei Shi; Zhong-Rong Li; Ming-Hua Qiu

doi:10.1007/s13659-013-0031-x

. 2013 May 29;3(3):99–102. doi: 10.1007/s13659-013-0031-x

New jatropholane-type diterpenes from Jatropha curcas cv. Multiflorum CY Yang

Yuan-Feng Yang ^1,², Jie-Qing Liu ¹, Lei Shi ^1,³, Zhong-Rong Li ¹, Ming-Hua Qiu ^1,^2,^✉

PMCID: PMC4131669

Abstract

Three new jatropholane-type diterpenoids, jatropholones C-E (1–3), along with seven other known compounds, including sikkimenoid B (4), jatrophaldehyde (5), epi-jatrophaldehyde (6), epi-jatrophol (7), jatrophol (8), jatropholone A (9), and jatropholone B (10), were isolated from the roots of a natural cultivar of Jatropha curcas (J. curcas cv. Multiflorum CY Yang). The structural elucidations of 1–3 were accomplished by extensive NMR analysis. Compounds 4, 6, and 8 demonstrated inhibition activity against the microorganisms with the MIC values from 0.10 to 0.18 mg/mL. graphic file with name 13659_2013_31_Article_Fig1_HTML.jpg

Electronic Supplementary Material

Supplementary material is available for this article at 10.1007/s13659-013-0031-x and is accessible for authorized users.

Keywords: Jatropha curcas cv. Multiflorum, Euphorbiaceae, diterpenes, antibacterial

Electronic supplementary material

13659_2013_31_MOESM1_ESM.pdf^{(1.1MB, pdf)}

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Footnotes

This article is published with open access at Springerlink.com

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Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

13659_2013_31_MOESM1_ESM.pdf^{(1.1MB, pdf)}

Supplementary material, approximately 1.07 MB.

[CR1] [1].The editor committee of Flora Repubulicae Popularis Sinicae, the Chinese academy of sciences. Euphorbiaceae (II) Subfam. Acalyphoideae Subfam. Crotonoideae. Science Press: Beijing, China, 1996; 44: 147–149.

[CR2] [2].http://www.xtbg.cas.cn/xwzx/kydt/201112/t20111223_3416898.html

[CR3] [3].Zhang X P, Zhang M L, Su X H, Huo C H, Gu Y C, Shi Q W. Chem. Biodiver. 2009;6:2166–2183. doi: 10.1002/cbdv.200700461. [DOI] [PubMed] [Google Scholar]

[CR4] [4].Sabandar C W, Ahmat N, Jaafar F M, Sahidin I. Phytochemistry. 2012;85:7–29. doi: 10.1016/j.phytochem.2012.10.009. [DOI] [PubMed] [Google Scholar]

[CR5] [5].Pertino M, Schmeda-Hirschmann G, Rodriguez J A, Theoduloz C. Planta Med. 2007;73:1095–1100. doi: 10.1055/s-2007-981580. [DOI] [PubMed] [Google Scholar]

[CR6] [6].Theoduloz C, Rodriguez J A, Pertino M. Planta Med. 2009;75:1520–1522. doi: 10.1055/s-0029-1185834. [DOI] [PubMed] [Google Scholar]

[CR7] [7].Goncalves de Moraes V L, Rumjanek V M, Calixto J B. Eur. J. Pharmacol. 1996;312:333–339. doi: 10.1016/0014-2999(96)00488-8. [DOI] [PubMed] [Google Scholar]

[CR8] [8].Sutthivaiyakit S, Mongkolvisut W, Prabpai S, Kongsaeree P. J. Nat. Prod. 2009;72:2024–2027. doi: 10.1021/np900342b. [DOI] [PubMed] [Google Scholar]

[CR9] [9].Taylor M D, Smith A B, III, Furst G T, Gunasekara S P, Bevelle C A, Cordell G A, Farnsworth N R, Kupchan S M, Uchida H, Branfman A R, Dailey R G, Sneden A T. J. Am. Chem. Soc. 1983;105:3177–3183. doi: 10.1021/ja00348a036. [DOI] [Google Scholar]

[CR10] [10].Kupchan S M, Sigel C W, Matz M J, Saenz Renauld J A, Haltiwanger R C, Bryan R F. J. Am. Chem. Soc. 1970;92:4476–4477. doi: 10.1021/ja00717a066. [DOI] [Google Scholar]

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[CR12] [12].http://www.xtbg.ac.cn/xwzx/kydt/201112/t20111223_3416898.html

[CR13] [13].Liu J Q, Yang Y F, Wang C F, Li Y, Qiu M H. Tetrahedron. 2012;68:972–976. doi: 10.1016/j.tet.2011.12.006. [DOI] [Google Scholar]

[CR14] [14].Yang Y F, Liu J Q, Li X Y, Liu E Q, Li Z R, Qiu M H. Chin. Sci. Bull. 2013;58:1–5. doi: 10.1007/s11434-012-5578-0. [DOI] [Google Scholar]

[CR15] [15].Yang D S, Zhang Y L, Peng W B, Wang L Y, Li Z L, Wang X, Liu K C, Yang Y P, Li H L, Li X L. J. Nat. Prod. 2013;76:265–269. doi: 10.1021/np300799n. [DOI] [PubMed] [Google Scholar]

[CR16] [16].Zhang X Q, Li F, Zhao Z G, Liu X L, Tang Y X, Wang M K. Phytochem. Lett. 2012;5:721–724. doi: 10.1016/j.phytol.2012.07.011. [DOI] [Google Scholar]

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[CR18] [18] (a).Purushothaman K K, Chandrasekharan S, Cameron A F, Connolly J D, Labbe C, Maltz A, Rycroft D S. Tetrahedron Lett. 1979;11:979–980. [Google Scholar]

[CR19] [18] (b).Kong L, Min Z, Shi J. Zhiwu Xuebao. 1996;38:161–166. [Google Scholar]

[CR20] [19].Miyazawa M, Uemura T, Kameoka H. Phytochemistry. 1994;37:1027–1030. doi: 10.1016/S0031-9422(00)89522-9. [DOI] [Google Scholar]

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PERMALINK

New jatropholane-type diterpenes from Jatropha curcas cv. Multiflorum CY Yang

Yuan-Feng Yang

Jie-Qing Liu

Lei Shi

Zhong-Rong Li

Ming-Hua Qiu

Abstract

Electronic Supplementary Material

Electronic supplementary material

Footnotes

References

Associated Data

Supplementary Materials

ACTIONS

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New jatropholane-type diterpenes from Jatropha curcas cv. Multiflorum CY Yang

Yuan-Feng Yang

Jie-Qing Liu

Lei Shi

Zhong-Rong Li

Ming-Hua Qiu

Abstract

Electronic Supplementary Material

Electronic supplementary material

Footnotes

References

Associated Data

Supplementary Materials

ACTIONS

PERMALINK

RESOURCES

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