Table 2.
Change in Fatigue Severity by Fatigue Severity Level at Baseline
| A. All patients | ||||
|---|---|---|---|---|
| Fatigue score at baseline |
No. of patients |
Better | No change | Worse |
| 0 | 622 | 0 (0.0) | 439 (70.6) | 183 (29.4) |
| 1–3 | 956 | 82 (8.6) | 542 (56.7) | 332 (34.7) |
| 1 | 356 | 0 (0.0) | 224 (62.9) | 132 (37.1) |
| 2–3 | 600 | 82 (13.7) | 318 (53.0) | 200 (33.3) |
| 4–6 | 664 | 208 (31.3) | 308 (46.4) | 148 (22.3) |
| 7–10 | 457 | 245 (53.6) | 186 (40.7) | 26 (5.7) |
| 7–8 | 301 | 151 (50.2) | 124 (41.2) | 26 (8.6) |
| 9–10 | 156 | 94 (60.3) | 62 (39.7) | 0 (0.0) |
| Total | 2699 | 535 (19.8) | 1475 (54.6) | 689 (25.5) |
| B. Patients with no current therapy | ||||
|---|---|---|---|---|
| Fatigue score at baseline |
No. of patients |
Better | No change | Worse |
| 0 | 230 | 0 (0.0) | 182 (79.1) | 48 (20.9) |
| 1–3 | 222 | 22 (9.9) | 128 (57.7) | 72 (32.4) |
| 1 | 86 | 0 (0.0) | 56 (65.1) | 30 (34.9) |
| 2–3 | 136 | 22 (16.2) | 72 (52.9) | 42 (30.9) |
| 4–6 | 135 | 45 (33.3) | 66 (48.9) | 24 (17.8) |
| 7–10 | 88 | 55 (62.5) | 27 (30.7) | 6 (6.8) |
| 7–8 | 55 | 31 (56.4) | 18 (32.7) | 6 (10.9) |
| 9–10 | 33 | 24 (72.7) | 9 (27.3) | 0 (0.0) |
| Total | 675 | 122 (18.1) | 403 (59.7) | 150 (22.2) |
| C. Patient with current therapy within 1 month | ||||
|---|---|---|---|---|
| Fatigue score at baseline |
No. of patients |
Better | No change | Worse |
| 0 | 104 | 0(0.0) | 55 (52.9) | 49 (47.2) |
| 1–3 | 195 | 16 (8.2) | 88 (45.1) | 91 (46.7) |
| 1 | 76 | 0(0.0) | 37 (48.7) | 39 (51.3) |
| 2–3 | 119 | 16 (13.4) | 51 (42.9) | 52 (43.7) |
| 4–6 | 122 | 31 (25.4) | 55 (45.1) | 36 (29.5) |
| 7–10 | 98 | 58 (59.2) | 35 (35.7) | 5 (5.1) |
| 7–8 | 64 | 34 (53.1) | 25 (39.1) | 5 (7.8) |
| 9–10 | 34 | 24 (70.6) | 10 (29.4) | 0 (0.0) |
| Total | 519 | 105 (20.2) | 233 (44.9) | 181 (34.9) |
| D. Patients with current therapy between 1 month and 1 year | ||||
|---|---|---|---|---|
| Fatigue score at baseline |
No. of patients |
Better | No change | Worse |
| 0 | 173 | 0(0.0) | 112 (64.7) | 61 (35.3) |
| 1–3 | 386 | 31 (8.0) | 224 (58.0) | 131 (33.9) |
| 1 | 140 | 0(0.0) | 91 (65.0) | 49 (35.0) |
| 2–3 | 246 | 31 (12.6) | 133 (54.1) | 82 (33.3) |
| 4–6 | 312 | 98 (31.4) | 139 (44.6) | 75 (24.0) |
| 7–10 | 207 | 94 (45.4) | 100 (48.3) | 13 (6.3) |
| 7–8 | 141 | 62 (44.0) | 66 (46.8) | 13 (9.2) |
| 9–10 | 66 | 32 (48.5) | 34 (51.5) | 0(0.0) |
| Total | 1,078 | 223 (20.7) | 575 (53.3) | 280 (26.0) |
| E. Patients with current therapy beyond 1 year | ||||
|---|---|---|---|---|
| Fatigue score at baseline |
No. of patients |
Better | No change | Worse |
| 0 | 112 | 0(0.0) | 87 (77.7) | 25 (22.3) |
| 1–3 | 151 | 13 (8.6) | 101 (66.9) | 37 (24.5) |
| 1 | 52 | 0(0.0) | 39 (75.0) | 13 (25.0) |
| 2–3 | 99 | 12 (13.1) | 62 (62.6) | 24 (26.2) |
| 4–6 | 92 | 32 (34.8) | 47 (51.1) | 13 (14.1) |
| 7–10 | 62 | 37 (59.7) | 23 (37.1) | 2 (3.2) |
| 7–8 | 39 | 23 (59.0) | 14 (35.9) | 2 (5.1) |
| 9–10 | 23 | 14 (60.9) | 9 (39.1) | 0(0.0) |
| Total | 417 | 82 (19.7) | 258 (61.9) | 77 (18.5) |
Note: Change in fatigue severity: worse was defined as >=2 point increase; better was defined as >=2 point decrease; no change was defined as <2 points change (either increase or decrease)