TABLE II.
Voxel-wise results of changes in dopamine (DA) during the SSTa
| Region/cluster | MNI coordinates
|
Cluster size (k) | Peak voxel (Z-score) | Baseline BPND (mean ± SD) | SST BPND (mean ± SD) | ΔBPND (mean ± SD) | ||
|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||
| Regions of increased DA | ||||||||
| Frontal | ||||||||
| SFG/SMA | −10 | 4 | 58 | 23 | 3.28 | 0.32 ± 0.087 | 0.28 ± 0.10 | 8.2 ± 5.2 |
| MFG | 30 | 10 | 44 | 37 | 2.99 | 0.29 ± 0.089 | 0.25 ± 0.10 | 19 ± 15 |
| 20 | −16 | 64 | 22 | 2.77 | 0.20 ± 0.078 | 0.16 ± 0.077 | 25 ± 19 | |
| 36 | 24 | 48 | 26 | 3.34 | 0.38 ± 0.076 | 0.35 ± 0.092 | 11 ± 8.2 | |
| OFC/IFG | −22 | 14 | −28 | 13 | 3.00 | 0.88 ± 0.17 | 0.83 ± 0.15 | 6.8 ± 4.1 |
| Parietal | ||||||||
| Precuneus | −8 | −62 | 36 | 141 | 3.52 | 0.39 ± 0.10 | 0.35 ± 0.10 | 1.2 ± 5.7 |
| 14 | −58 | 62 | 33 | 3.30 | 0.29 ± 0.069 | 0.26 ± 0.062 | 15 ± 12 | |
| IPL/SMG | 64 | −36 | 34 | 28 | 3.33 | 0.37 ± 0.15 | 0.32 ± 0.13 | 12 ± 3.8 |
| Angular gyrus | 50 | −62 | 30 | 26 | 3.15 | 0.59 ± 0.17 | 0.55 ± 0.17 | 7.1 ± 5.0 |
| Paracentral lobule | 6 | −32 | 68 | 22 | 3.06 | 0.19 ± 0.10 | 0.16 ± 0.087 | 12 ± 9.0 |
| Postcentral gyrus | 62 | −14 | 16 | 85 | 3.01 | 0.53 ± 0.21 | 0.47 ± 0.19 | 8.2 ± 5.4 |
| Precentral gyrus | 46 | −10 | 32 | 22 | 2.81 | 0.26 ± 0.072 | 0.22 ± 0.076 | 16 ± 13 |
| Temporal | ||||||||
| Fusiform gyrus | −28 | −50 | −16 | 25 | 3.21 | 0.69 ± 0.20 | 0.64 ± 0.18 | 5.9 ± 4.0 |
| −40 | −38 | −26 | 45 | 3.12 | 0.89 ± 0.26 | 0.83 ± 0.23 | 16 ± 11 | |
| STG | 60 | −50 | 14 | 21 | 3.18 | 0.62 ± 0.19 | 0.58 ± 0.19 | 6.5 ± 5.0 |
| 62 | −36 | 12 | 51 | 3.06 | 0.61 ± 0.16 | 0.56 ± 0.16 | 17 ± 8.3 | |
| Other | ||||||||
| Cingulate cortex | 4 | −20 | 40 | 14 | 3.34 | 0.61 ± 0.11 | 0.58 ± 0.11 | 5.9 ± 3.6 |
| 10 | 12 | 42 | 22 | 3.00 | 0.49 ± 0.11 | 0.45 ± 0.12 | 9.3 ± 6.5 | |
| −10 | −12 | 40 | 11 | 2.81 | 0.27 ± 0.083 | 0.22 ± 0.070 | 6.5 ± 4.0 | |
| Uncus | −32 | −14 | −38 | 10 | 3.01 | 1.1 ± 0.37 | 1.0 ± 0.35 | 15 ± 10 |
| Regions of decreased DA | ||||||||
| ACC | −2 | 30 | −4 | 16 | 3.13 | 0.22 ± 0.11 | 0.27 ± 0.11 | −34 ± 32 |
a
Regions of increased DA were taken from the BPND, BL>BPND, SS contrast. Regions of decreased DA were taken from the BPND, SS>BPND, BL contrast. MNI, Montreal Neurological Institute; k, cluster size; SST, stop signal task; STG, superior temporal gyrus; IPL, inferior parietal lobe; SMG, supramarginal gyrus; SMA, supplementary motor area; ITG, inferior temporal gyrus; MFG, middle frontal gyrus; SFG, superior frontal gyrus; IFG, inferior frontal gyrus; OFC, orbitofrontal cortex; ACC, anterior cingulate cortex. Statistical threshold was P<.005, uncorrected, k>10 voxels.