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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Nat Chem Biol. 2014 Jul 20;10(9):716–722. doi: 10.1038/nchembio.1580

Figure 2.

Figure 2

Visualization of different loop structures observed among the hot loops. Representative examples of each type of loop are shown within each circle, including: β-turns (2ZZC), Schellman loops (2OL1), αβ-motifs (2DVT), β-bulges (3GBT), β-hairpins (1T3I), Asx-turns and motifs (1LIA), S/T-turns, motifs and staples (1Y1X), and γ-turns (2IX5). The remaining two categories shown above are α-helical regions identified by their backbone torsional angles (2BM8), and loops lacking canonical structural motifs (3KYH). All structures, rendered in Pymol,42 show the hot loop in green and hot spots in orange (ΔΔGresidue ≥ 1 kcal/mol) or yellow (ΔΔGresidue ≥ 2 kcal/mol).