Table 1. Allelic Association to SNPs in a 5.3-Mb Region Surrounding GABRB3 in 34 Sardinian PD Trios.
SNP | Position, Feb 2009 (hg19) | p(TDT) | OR (95% CI) | p(emp) |
---|---|---|---|---|
rs10220768 | chr15:24319693 | 0.002 | 0.27 (0.11, 0.67) | 0.008 |
rs2912586 | chr15:26783311 | 0.004 | 3.80 (1.42, 10.18) | 0.008 |
rs2017247 | chr15:26789162 | 0.004 | 3.80 (1.42, 10.18) | 0.008 |
rs8029900 | chr15:24867594 | 0.007 | 4.00 (1.34, 11.96) | 0.015 |
rs12914251 | chr15:24889850 | 0.007 | 4.00 (1.34, 11.96) | 0.015 |
rs1382058 | chr15:27758904 | 0.009 | 0.38 (0.17, 0.81) | 0.01 |
rs4778471 | chr15:22964125 | 0.009 | 3.17 (1.27, 7.93) | 0.018 |
Abbreviations: OR (95% CI), odds ratio of TDT with 95% confidence interval; PD, panic disorder; p(EMP), pointwise empirical p-value after 1 million permutations; p(TDT), p-value of TDT; SNP, single-nucleotide polymorphism.
Position, location at the UCSC genome browser (hg19, build GRCHr37). Results are shown for SNPs with p(TDT) <0.01. The SNPs rs2912586 and rs2017247 show an r2=1.0, as rs8029900 and rs12914251.