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. 1993 Dec;12(12):4829–4832. doi: 10.1002/j.1460-2075.1993.tb06172.x

Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.

G Mignogna 1, M Simmaco 1, G Kreil 1, D Barra 1
PMCID: PMC413935  PMID: 8223491

Abstract

A family of bombinin-related peptides is present in the skin of Bombina variegata. These peptides contain 27 residues with Gly as N-terminus and display antimicrobial activity. From sequence analysis of the cDNAs encoding for the corresponding peptide precursors, the presence of a novel 20-residue peptide with Ile as N-terminus was predicted. We have now purified a family of hydrophobic peptides named H1-H5, whose sequences correspond to the predicted peptide with some variability in positions 1, 2 and 8. In particular, H3-H5 contain a D-alloisoleucine residue in the second position. All these peptides display antibacterial and haemolytic activity.

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Selected References

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