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. 1978 Jan;19(1):107–115. doi: 10.1128/iai.19.1.107-115.1978

Specificity of salivary-bacterial interactions: role of terminal sialic acid residues in the interaction of salivary glycoproteins with Streptococcus sanguis and Streptococcus mutans.

M J Levine, M C Herzberg, M S Levine, S A Ellison, M W Stinson, H C Li, T van Dyke
PMCID: PMC414055  PMID: 415001

Abstract

Four highly purified salivary glycoproteins were used to study salivary-bacterial interactions. One pair of glycoproteins was mucin-like in composition, whereas the second pair was not. By an agglutination assay, it was found that only the mucin-glycoproteins agglutinated Streptococcus sanguis and S. mutans. Removal of sialic acid from these molecules resulted in a loss of agglutination of S. sanguis but not of S. mutans. The agglutination phenomenon was shown to require a salivary macromolecule of at least 150,000 daltons.

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Selected References

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