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. Author manuscript; available in PMC: 2014 Aug 21.
Published in final edited form as: Neuroscientist. 2011 Jun 7;18(3):271–286. doi: 10.1177/1073858411404228

Figure 5. Two closely related members of FGF and neuroligin protein families selectively organize glutamatergic and GABAergic synapse formation.

Figure 5

Steps of synapse formation include (A) Synaptic differentiation: FGF22 and FGF7 specifically released from glutamatergic or GABAergic postsynaptic sites promote accumulation of corresponding synaptic vesicles to the presynaptic terminal. (B) Synaptic maturation: neuroligin1 at glutamatergic postsynaptic terminals and neuroligin2 at GABAergic postsynaptic terminals maturate each synapse through their receptor neurexins. (C) Synaptic modification: neural activity-dependent mechanisms are involved in synapse refinement and plasticity.