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. 1978 Feb;19(2):353–356. doi: 10.1128/iai.19.2.353-356.1978

Induction of interferon synthesis in mice by fractions from Nocardia.

R Barot-Ciorbaru, J Wietzerbin, J F Petit, L Chedid, E Falcoff, E Lederer
PMCID: PMC414089  PMID: 75845

Abstract

Three fractions of Nocardia, Nocardia water-soluble mitogen (NWSM), Nocardia water-soluble mitogen pellet (NWSMP), and the cell wall peptidoglycan, which are mitogenic for B lymphocytes, were able to induce circulating interferon in mice, NWSMP and NWSM being the most active. The peak of interferon appeared about 2 h after injection. The interferon induced by NSWMP and NWSM was acid stable and antigenically related to viral interferon, as shown by neutralization with antibodies directed against Newcastle disease virus-induced interferon.

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Selected References

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