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. Author manuscript; available in PMC: 2015 May 7.
Published in final edited form as: Neuron. 2014 May 7;82(3):659–669. doi: 10.1016/j.neuron.2014.03.011

Figure 7. Enhanced cocaine locomotor response in SNX27DA KO mice.

Figure 7

(A) Total distance traveled in novel open field environment by WT (n=18), DAT-Cre+/− (n=17), and SNX27DA KO (n=17) mice over 1 hour (**p<0.01 vs WT, p<0.05 vs DAT-Cre+/−, one-way ANOVA with Bonferroni post hoc test). (B) No significant change in thigmotaxis for SNX27DA KO mice (n=12) vs. WT (n=11) or vs. DAT-Cre+/− (n=11). Time spent in center of chamber (central 10” squared of 16” squared chamber, n.s. one-way ANOVA). (C) Heightened sensitivity to cocaine in SNX27DA KO mice. Locomotor activity measured in WT (n=6), DAT-Cre+/− (n=16) or SNX27DA KO (n=14) mice following a single injection (i.p.) of saline (0.9%) or cocaine (20mg/kg). (**p<0.05 cocaine vs. saline, two-way ANOVA with Bonferroni post hoc test). (D) Fold increase in locomotor activity with cocaine measured over 30 minute period. (**p<0.05, One-way ANOVA with Bonferroni post hoc test).