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. 1978 Feb;19(2):613–620. doi: 10.1128/iai.19.2.613-620.1978

Granuloma formation by synthetic bacterial cell wall fragment: muramyl dipeptide.

K Emori, A Tanaka
PMCID: PMC414127  PMID: 75847

Abstract

A synthetic muramyl dipeptide, N-acetylmuramyl-L-alanyl-D-isoglutamine, which possesses the same structure as that of a part of the peptidoglycan monomer of wax D of tubercle bacilli or bacterial cell walls was found to induce, when injected in water-in-oil emulsion, massive granulomas often accompanying abscesses in the site of injection and draining lymph nodes of guinea pigs and rats. The granulomas were composed mainly of epithelioid cells 2 weeks after injection and were indistinguishable from those induced by tubercle bacilli. The granulomas induced in rats were less mature than those induced in guinea pigs. Allergic reaction appeared to play no important role in the development of the muarmyl dipeptide-induced granuloma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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