Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1978 Feb;19(2):737–740. doi: 10.1128/iai.19.2.737-740.1978

Immunity to experimental renal candidiasis in rats.

T J Rogers, E Balish
PMCID: PMC414141  PMID: 344222

Abstract

Germfree rats were found to be more susceptible to intravenous challenge with Candida albicans than were conventional rats. The resistance of conventional rats could be overcome by increasing the challenge dose. The resistance of the germfree rat was enhanced by vaccination with Formalin-killed C. albicans in complete Freund adjuvant, complete Freund adjuvant, or incomplete Freund adjuvant. These results, and histological evidence obtained from infected gnotobiotic rats, provided further information on the mechanism of resistance to the disseminated form of candidiasis.

Full text

PDF

Images in this article

738Image
on p.738
739Image
on p.739

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer H., Paronetto F., Burns W. A., Einheber A. The enhancing effect of the microbial flora on macrophage function and the immune response. A study in germfree mice. J Exp Med. 1966 Jun 1;123(6):1013–1024. doi: 10.1084/jem.123.6.1013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. HASENCLEVER H. F., MITCHELL W. O. ACQUIRED IMMUNITY TO CANDIDIASIS IN MICE. J Bacteriol. 1963 Sep;86:401–406. doi: 10.1128/jb.86.3.401-406.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HOROWITZ R. E., BAUER H., PARONETTO F., ABRAMS G. D., WATKINS K. C., POPPER H. THE RESPONSE OF THE LYMPHATIC TISSUE TO BACTERIAL ANTIGEN. STUDIES IN GERMFREE MICE. Am J Pathol. 1964 May;44:747–761. [PMC free article] [PubMed] [Google Scholar]
  4. Kirkpatrick C. H., Chandler J. W., Schimke R. N. Chronic mucocutaneous moniliasis with impaired delayed hypersensitivity. Clin Exp Immunol. 1970 Mar;6(3):375–385. [PMC free article] [PubMed] [Google Scholar]
  5. Kirkpatrick C. H., Rich R. R., Bennett J. E. Chronic mucocutaneous candidiasis: model-building in cellular immunity. Ann Intern Med. 1971 Jun;74(6):955–978. doi: 10.7326/0003-4819-74-6-955. [DOI] [PubMed] [Google Scholar]
  6. Lehrer R. I., Cline M. J. Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. J Clin Invest. 1969 Aug;48(8):1478–1488. doi: 10.1172/JCI106114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lehrer R. I. Measurement of candidacidal activity of specific leukocyte types in mixed cell populations I. Normal, myeloperoxidase-deficient, and chronic granulomatous disease neutrophils. Infect Immun. 1970 Jul;2(1):42–47. doi: 10.1128/iai.2.1.42-47.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Marra S., Balish E. Immunity to Candida albicans induced by Listeria monocytogenes. Infect Immun. 1974 Jul;10(1):72–82. doi: 10.1128/iai.10.1.72-82.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mourad S., Friedman L. Passive immunization of mice against Candida albicans. Sabouraudia. 1968 Feb;6(2):103–105. [PubMed] [Google Scholar]
  10. Olson G. B., Wostmann B. S. Lymphocytopoiesis, plasmacytopoiesis and cellular proliferation in nonantigenically stimulated germfree mice. J Immunol. 1966 Aug;97(2):267–274. [PubMed] [Google Scholar]
  11. Pollard M., Sharon N. Responses of the Peyer's Patches in Germ-Free Mice to Antigenic Stimulation. Infect Immun. 1970 Jul;2(1):96–100. doi: 10.1128/iai.2.1.96-100.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rogers T. J., Balish E., Manning D. D. The role of thymus-dependent cell-mediated immunity in resistance to experimental disseminated candidiasis. J Reticuloendothel Soc. 1976 Oct;20(4):291–298. [PubMed] [Google Scholar]
  13. Rogers T. J., Balish E. The role of activated macrophages in resistance to experimental renal candidiasis. J Reticuloendothel Soc. 1977 Oct;22(4):309–318. [PubMed] [Google Scholar]
  14. Rogers T., Balish E. Experimental Candida albicans infection in conventional mice and germfree rats. Infect Immun. 1976 Jul;14(1):33–38. doi: 10.1128/iai.14.1.33-38.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sohnle P. G., Frank M. M., Kirkpatrick C. H. Mechanisms involved in elimination of organisms from experimental cutaneous Candida albicans infections in guinea pigs. J Immunol. 1976 Aug;117(2):523–530. [PubMed] [Google Scholar]
  16. Valdimarsson H., Wood C. B., Hobbs J. R., Holt P. J. Immunological features in a case of chronic granulomatous candidiasis and its treatment with transfer factor. Clin Exp Immunol. 1972 Jun;11(2):151–163. [PMC free article] [PubMed] [Google Scholar]
  17. al-Doory Y. An immune factor in baboon anti-candida serum. Sabouraudia. 1970 May;8(1):41–47. doi: 10.1080/00362177085190621. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES