Abstract
Splenomegaly resulting from Trypanosoma musculi infection was found to be dependent upon a functioning T-lymphocyte system. When both humoral and cell-mediated immune systems were suppressed by treatment with cyclophosphamide 2 days after infection, splenomegaly was inhibited for about 6 days. However, when only humoral immunity was suppressed by treatment with cyclophosphamide 3 days before infection, splenomegaly still occurred. In addition, splenomegaly was absent in congenitally athymic nude mice. Nude mice and immunologically intact heterozygote mice were also sacrificed at varying times after infection, and spleens were examined histologically. A lymphocytic hyperplasia was observed in immunologically intact mice but not in nude mice. These data indicate that splenomegaly of T. musculi infections is T cell dependent and that splenomegaly is the result of a proliferation of B and/or T lymphocytes.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Albright J. F., Albright J. W., Dusanic D. G. Trypanosome-induced splenomegaly and suppression of mouse spleen cell responses to antigen and mitogens. J Reticuloendothel Soc. 1977 Jan;21(1):21–31. [PubMed] [Google Scholar]
- Buhles W. C., Jr, Shifrine M. Effects of cyclophosphamide on macrophage numbers, functions and progenitor cells. J Reticuloendothel Soc. 1977 May;21(5):285–297. [PubMed] [Google Scholar]
- Jarvinen J. A., Dalmasso A. P. Trypanosoma musculi: immunologic features of the anemia in infected mice. Exp Parasitol. 1977 Oct;43(1):203–210. doi: 10.1016/0014-4894(77)90024-8. [DOI] [PubMed] [Google Scholar]
- Jayawardena A. N., Targett G. A., Carter R. L., Leuchars E., Davies A. J. The immunological response of CBA mice to P. yoelii. I. General characteristics, the effects of T-cell deprivation and reconstitution with thymus grafts. Immunology. 1977 Jun;32(6):849–859. [PMC free article] [PubMed] [Google Scholar]
- Kolb J. P., Poupon M. F., Lespinats G. M., Sabolovic D., Loisillier F. Splenic modifications induced by cyclophosphamide in C3H/He, nude, and "B" mice. J Immunol. 1977 May;118(5):1595–1599. [PubMed] [Google Scholar]
- Rank R. G., Roberts D. W., Weidanz W. P. Chronic infection with Trypanosoma musculi in congenitally athymic nude mice. Infect Immun. 1977 May;16(2):715–716. doi: 10.1128/iai.16.2.715-716.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts D. W., Weidanz W. P. Splenomegaly, enhanced phagocytosis, and anemia are thymus-dependent responses to malaria. Infect Immun. 1978 Jun;20(3):728–731. doi: 10.1128/iai.20.3.728-731.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Turk J. L., Parker D., Poulter L. W. Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide. Immunology. 1972 Oct;23(4):493–501. [PMC free article] [PubMed] [Google Scholar]
- Turk J. L., Polak L., Parker D. Control mechanisms in delayed-type hypersensitivity. Br Med Bull. 1976 May;32(2):165–170. doi: 10.1093/oxfordjournals.bmb.a071350. [DOI] [PubMed] [Google Scholar]
- Turk J. L., Poulter L. W. Selective depletion of lymphoid tissue by cyclophosphamide. Clin Exp Immunol. 1972 Feb;10(2):285–296. [PMC free article] [PubMed] [Google Scholar]
- Viens P., Targett G. A., Leuchars E., Davies A. J. The immunological response of CBA mice to Trypanosoma musculi. I. Initial control of the infection and the effect of T-cell deprivation. Clin Exp Immunol. 1974 Feb;16(2):279–294. [PMC free article] [PubMed] [Google Scholar]
- Wyler D. J., Gallin J. I. Spleen-derived mononuclear cell chemotactic factor in malaria infections: a possible mechanism for splenic macrophage accumulation. J Immunol. 1977 Feb;118(2):478–484. [PubMed] [Google Scholar]
- Zembala M., Asherson G. L. The effect of cyclophosphamide and irradiation on cells which suppress contact sensitivity in the mouse. Clin Exp Immunol. 1976 Mar;23(3):554–561. [PMC free article] [PubMed] [Google Scholar]