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. 1979 Feb;23(2):282–286. doi: 10.1128/iai.23.2.282-286.1979

Chemotactic deactivation of human neutrophils: possible relationship to stimulation of oxidative metabolism.

R D Nelson, R T McCormack, V D Fiegel, M Herron, R L Simmons, P G Quie
PMCID: PMC414161  PMID: 422242

Abstract

Neutrophils preexposed to high concentrations of activated complement or synthetic N-formyl methionyl peptides are inhibited in their subsequent spontaneous and chemotactic migratory responses. We have considered the possibility that a part of this nonspecific loss of migratory function may be attributable to the interaction of the leukocytes with reactive forms of oxygen deriving from the cytotaxin-induced burst of oxidative metabolic activity. For these studies we have assessed the effect of preexposure of neutrophils from patients with chronic granulomatous disease to cytotaxins on their subsequent migratory responses. We find that these responses are not altered by preexposure to either cytotaxin. Thus, there appears to be a functional relationship between deactivation and the ability of the normal neutrophil to undergo a cytotaxin-induced respiratory burst.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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