Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1979 Feb;23(2):360–365. doi: 10.1128/iai.23.2.360-365.1979

Adjuvants in the induction of suppressor cells.

R Neta, S B Salvin
PMCID: PMC414173  PMID: 370015

Abstract

The effect of different mycobacterial adjuvants on the parameters of delayed hypersensitivity was investigated in strain 13 guinea pigs. The composition of the tubercle bacilli and the type of vehicle in which the antigen was presented determined the presence and extent of suppressor cell activity. When antigen was introduced in complete Freund adjuvant, both adherent and nonadherent cells had suppressive properties, with the suppressive effect demonstrable in vitro from 1 to 5 weeks after sensitization. Suppressor activity was indicated in vivo by a reduction of delayed footpad hypersensitivity in animals presensitized with complete Freund adjuvant.

Full text

PDF
360

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allwood G. G., Asherson G. L. Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. II. Mechanism of the phenomenon. Clin Exp Immunol. 1971 Aug;9(2):259–266. [PMC free article] [PubMed] [Google Scholar]
  2. Baker P. J., Stashak P. W., Amsbaugh D. F., Prescott B. Regulation of the antibody response to type 3 pneumococcal polysaccharide. II. Mode of action of thymic-derived suppressor cells. J Immunol. 1974 Jan;112(1):404–409. [PubMed] [Google Scholar]
  3. Feldman J. D. Immunological enhancement: a study of blocking antibodies. Adv Immunol. 1972;15:167–214. doi: 10.1016/s0065-2776(08)60685-9. [DOI] [PubMed] [Google Scholar]
  4. Fujimoto S., Greene M. I., Sehon A. H. Regualtion of the immune response to tumor antigens. I. Immunosuppressor cells in tumor-bearing hosts. J Immunol. 1976 Mar;116(3):791–799. [PubMed] [Google Scholar]
  5. Gershon R. K. T cell control of antibody production. Contemp Top Immunobiol. 1974;3:1–40. doi: 10.1007/978-1-4684-3045-5_1. [DOI] [PubMed] [Google Scholar]
  6. Ha T. Y., Waksman B. H. Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients. J Immunol. 1973 May;110(5):1290–1299. [PubMed] [Google Scholar]
  7. JANKOVIC B. D. Impairment of immunological reactivity in guinea pigs by prior injection of adjuvant. Nature. 1962 Feb 24;193:789–790. doi: 10.1038/193789a0. [DOI] [PubMed] [Google Scholar]
  8. MACKANESS G. B. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE. J Exp Med. 1964 Jul 1;120:105–120. doi: 10.1084/jem.120.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Neta R., Salvin S. B. Specific depression of delayed hypersensitivity to purified proteins, with relation to production of circulating antibody. Cell Immunol. 1973 Nov;9(2):242–250. doi: 10.1016/0008-8749(73)90075-0. [DOI] [PubMed] [Google Scholar]
  10. Neta R., Salvin S. B. Specific suppression of delayed hypersensitivity: the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity. J Immunol. 1974 Dec;113(6):1716–1725. [PubMed] [Google Scholar]
  11. Neta R., Salvin S. B. T and B lymphocytes in the regulation of delayed hypersensitivity. J Immunol. 1976 Nov;117(5 PT2):2014–2020. [PubMed] [Google Scholar]
  12. Neta R., Winkelstein A., Salvin S. B., Mendelow H. The effect of cyclophosphamide on suppressor cells in guinea pigs. Cell Immunol. 1977 Oct;33(2):402–411. doi: 10.1016/0008-8749(77)90168-x. [DOI] [PubMed] [Google Scholar]
  13. Reinisch C. L., Gleiner N. A., Schlossman S. F. Adjuvant regulation of T cell function. J Immunol. 1976 Mar;116(3):710–715. [PubMed] [Google Scholar]
  14. Salvin S. B., Neta R. A possible relationship between delayed hypersensitivity and cell-mediated immunity. Am Rev Respir Dis. 1975 Apr;111(4):373–377. doi: 10.1164/arrd.1975.111.4.373. [DOI] [PubMed] [Google Scholar]
  15. Salvin S. B., Nishio J. Communications. "In vitro" cell reactions in delayed hypersensitivity. J Immunol. 1969 Jul;103(1):138–141. [PubMed] [Google Scholar]
  16. Salvin S. B., Ribi E., Granger D. L., Youngner J. S. Migration inhibitory factor and type II interferon in the circulation of mice sensitized with mycobacterial components. J Immunol. 1975 Jan;114(1 Pt 2):354–359. [PubMed] [Google Scholar]
  17. Swierkosz J. E., Swanborg R. H. Suppressor cell control of unresponsiveness to experimental allergic encephalomyelitis. J Immunol. 1975 Sep;115(3):631–633. [PubMed] [Google Scholar]
  18. Veit B. C., Feldman J. D. Altered lymphocyte functions in rats bearing syngeneic Moloney sarcoma tumors. II. Suppressor cells. J Immunol. 1976 Aug;117(2):655–660. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES