Skip to main content

Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.

Infection and Immunity logoLink to Infection and Immunity
. 1979 Feb;23(2):398–402. doi: 10.1128/iai.23.2.398-402.1979

Defective cellular immunity to gram-negative bacteria in cystic fibrosis patients.

R U Sorensen, R C Stern, P Chase, S H Polmar
PMCID: PMC414178  PMID: 106011

Abstract

In vitro lymphocyte responses to Pseudomonas aeruginosa have been found to be impaired in cystic fibrosis patients with advanced clinical disease. The responses to Klebsiella pneumoniae, Serratia marcescens, and Proteus mirabilis were studied in a similar group of cystic fibrosis patients and normal individuals. Cystic fibrosis patients found to be unresponsive to pseudomonas were also unresponsive to klebsiella, serratia, and proteus. Responsiveness to Staphylococcus aureus was not impaired in cystic fibrosis patients. We postulate that in vitro lymphocyte responses to several gram-negative bacteria require the function of a lymphocyte subpopulation which may be impaired in some cystic fibrosis patients.

Full text

PDF
398

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chandra R. K. Lymphocyte subpopulations in human malnutrition: cytotoxic and suppressor cells. Pediatrics. 1977 Mar;59(3):423–427. [PubMed] [Google Scholar]
  2. DOERSHUK C. F., MATTHEWS L. W., TUCKER A. S., NUDLEMAN H., EDDY G., WISE M., SPECTOR S. A 5 YEAR CLINICAL EVALUATION OF A THERAPEUTIC PROGRAM FOR PATIENTS WITH CYSTIC FIBROSIS. J Pediatr. 1964 Nov;65:677–693. doi: 10.1016/s0022-3476(64)80152-9. [DOI] [PubMed] [Google Scholar]
  3. Ferguson A. C., Lawlor G. J., Jr, Neumann C. G., Oh W., Stiehm E. R. Decreased rosette-forming lymphocytes in malnutrition and intrauterine growth retardation. J Pediatr. 1974 Nov;85(5):717–723. doi: 10.1016/s0022-3476(74)80527-5. [DOI] [PubMed] [Google Scholar]
  4. GREEN G. M., KASS E. H. THE ROLE OF THE ALVEOLAR MACROPHAGE IN THE CLEARANCE OF BACTERIA FROM THE LUNG. J Exp Med. 1964 Jan 1;119:167–176. doi: 10.1084/jem.119.1.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Green G. M. The J. Burns Amberson Lecture--in defense of the lung. Am Rev Respir Dis. 1970 Nov;102(5):691–703. doi: 10.1164/arrd.1970.102.5.691. [DOI] [PubMed] [Google Scholar]
  6. Hoiby N., Mathiesen L. Pseudomonas aeruginosa infection in cystic fibrosis. Distribution of B and T lymphocytes in relation to the humoral immune response. Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Aug;82(4):559–566. [PubMed] [Google Scholar]
  7. Kaltreider H. B. Expression of immune mechanisms in the lung. Am Rev Respir Dis. 1976 Mar;113(3):347–379. doi: 10.1164/arrd.1976.113.3.347. [DOI] [PubMed] [Google Scholar]
  8. Lieberman J., Kaneshiro W. Abnormal response of cultured lymphocytes to phytohemagglutinin and autologous serum in cystic fibrosis. Am Rev Respir Dis. 1977 Dec;116(6):1047–1055. doi: 10.1164/arrd.1977.116.6.1047. [DOI] [PubMed] [Google Scholar]
  9. Moore V. L., Myrvik Q. N. The role of normal alveolar macrophages in cell-mediated immunity. J Reticuloendothel Soc. 1977 Feb;21(2):131–139. [PubMed] [Google Scholar]
  10. Neumann C. G., Lawlor G. J., Jr, Stiehm E. R., Swenseid M. E., Newton C., Herbert J., Ammann A. J., Jacob M. Immunologic responses in malnourished children. Am J Clin Nutr. 1975 Feb;28(2):89–104. doi: 10.1093/ajcn/28.2.89. [DOI] [PubMed] [Google Scholar]
  11. SHWACHMAN H., KULCZYCKI L. L. Long-term study of one hundred five patients with cystic fibrosis; studies made over a five- to fourteen-year period. AMA J Dis Child. 1958 Jul;96(1):6–15. doi: 10.1001/archpedi.1958.02060060008002. [DOI] [PubMed] [Google Scholar]
  12. Sellmeyer E., Bhettay E., Truswell A. S., Meyers O. L., Hansen J. D. Lymphocyte transformation in malnourished children. Arch Dis Child. 1972 Jun;47(253):429–435. doi: 10.1136/adc.47.253.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sorensen R. U., Stern R. C., Polmar S. H. Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients. Infect Immun. 1977 Dec;18(3):735–740. doi: 10.1128/iai.18.3.735-740.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sorensen R. U., Stern R. C., Polmar S. H. Lymphocyte responsiveness to Pseudomonas aeruginosa in cystic fibrosis: Relationship to status of pulmonary disease in sibling pairs. J Pediatr. 1978 Aug;93(2):201–205. doi: 10.1016/s0022-3476(78)80496-x. [DOI] [PubMed] [Google Scholar]
  15. WEIGLE W. O. STUDIES ON THE TERMINATION OF ACQUIRED TOLERANCE TO SERUM PROTEIN ANTIGENS FOLLOWING INJECTION OF SEROLOGICALLY RELATED ANTIGENS. Immunology. 1964 May;7:239–247. [PMC free article] [PubMed] [Google Scholar]
  16. WEIGLE W. O. THE IMMUNE RESPONSE OF RABBITS TOLERANT TO ONE PROTEIN CONJUGATE FOLLOWING THE INJECTION OF RELATED PROTEIN CONJUGATES. J Immunol. 1965 Feb;94:177–183. [PubMed] [Google Scholar]
  17. WEIGLE W. O. THE INDUCTION OF AUTOIMMUNITY IN RABBITS FOLLOWING INJECTION OF HETEROLOGOUS OR ALTERED HOMOLOGOUS THYROGLOBULIN. J Exp Med. 1965 Feb 1;121:289–308. doi: 10.1084/jem.121.2.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wallwork J. C., Brenchley P., McCarthy J., Allan J. D., Moss D., Ward A. M., Holzel A., Williams R. F., McFarlane H. Some aspects of immunity in patients with cystic fibrosis. Clin Exp Immunol. 1974 Nov;18(3):303–320. [PMC free article] [PubMed] [Google Scholar]
  19. Warr G. A., Martin R. R. Response of human pulmonary macrophage to migration inhibition factor. Am Rev Respir Dis. 1973 Aug;108(2):371–373. doi: 10.1164/arrd.1973.108.2.371. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES