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Postulated role of PI3K/PKCδ, PI3K/PKCζ in Rab4-mediated insertion of NTCP into PM. NTCP containing vesicles co-localize with Rab4, which cycles between GTP bound (Rab4-GTP) active form and GDP bound (Rab4-GDP) inactive form. Activation of PKCδ leads to the conversion of inactive Rab4-GDP to active Rab4-GTP followed by recruitment of kinesin-1, which moves NTCP containing vesicles towards the plus end of microtubules (Mt). This movement is further facilitated by PKCζ.
