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. 1979 Mar;23(3):686–689. doi: 10.1128/iai.23.3.686-689.1979

Production of a mutagen from ponceau 3R by a human intestinal anaerobe.

C P Hartman, A W Andrews, K T Chung
PMCID: PMC414220  PMID: 457255

Abstract

Ponceau 3R was reduced in vitro by Fusobacterium sp. 2, a human intestinal anaerobe, to a product which is mutagenic when metabolically activated by liver S9 preparations in the Salmonella/mammalian-microsome mutagenicity test. This mutagenic metabolite has been identified as 2,4,5-trimethylaniline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames B. N., Durston W. E., Yamasaki E., Lee F. D. Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci U S A. 1973 Aug;70(8):2281–2285. doi: 10.1073/pnas.70.8.2281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chung K. T., Fulk G. E., Egan M. Reduction of azo dyes by intestinal anaerobes. Appl Environ Microbiol. 1978 Mar;35(3):558–562. doi: 10.1128/aem.35.3.558-562.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chung K. T., Fulk G. E., Slein M. W. Tryptophanase of fecal flora as a possible factor in the etiology of colon cancer. J Natl Cancer Inst. 1975 May;54(5):1073–1078. doi: 10.1093/jnci/54.5.1073. [DOI] [PubMed] [Google Scholar]
  4. Lindstrom H. V., Bowie W. C., Wallace W. C., Nelson A. A., Fitzhugh O. G. The toxicity and metabolism of mesidine and pseudocumidine in rats. J Pharmacol Exp Ther. 1969 Jun;167(2):223–234. [PubMed] [Google Scholar]
  5. McCann J., Choi E., Yamasaki E., Ames B. N. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135–5139. doi: 10.1073/pnas.72.12.5135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Roxon J. J., Ryan A. J., Wright S. E. Enzymatic reduction of tartrazine by Proteus vulgaris from rats. Food Cosmet Toxicol. 1967 Nov;5(5):645–656. doi: 10.1016/s0015-6264(67)83216-4. [DOI] [PubMed] [Google Scholar]

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