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. 1979 May;24(2):352–356. doi: 10.1128/iai.24.2.352-356.1979

Hepatitis B e-antigen and its correlation with other serological markers in chimpanzees.

C M Ling, I K Mushahwar, L R Overby, K R Berquist, J E Maynard
PMCID: PMC414308  PMID: 457278

Abstract

Three chimpanzees experimentally infected with hepatitis B virus, and another three chimpanzees that were hepatitis surface antigen carriers, were studied for the presence of viral antigens and humoral immune responses. Quantitative analyses of hepatitis B surface and e-antigens in sequential serum samples at early acute stages revealed cyclic oscillations of these two antigens following a synchronous pattern. Similar analyses of anti-e-antigen and anti-hepatitis B core antigen antibodies from the three experimentally infected primates indicated that peak titers of these two antibodies occurred as surface antigen decreased to undetectable levels. Of the three surface-antigen carriers, two were positive for e-antigen and one was positive for e-antigen antibody for the entire course of surveillance (8, 9, and 22 months, respectively).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aikawa T., Sairenji H., Furuta S., Kiyosawa K., Shikata T., Imai M., Miyakawa Y., Yanase Y., Mayumi M. Seroconversion from hepatitis B e antigen to anti-HBe in acute hepatitis B virus infection. N Engl J Med. 1978 Feb 23;298(8):439–441. doi: 10.1056/NEJM197802232980807. [DOI] [PubMed] [Google Scholar]
  2. Alter H. J., Seeff L. B., Kaplan P. M., McAuliffe V. J., Wright E. C., Gerin J. L., Purcell R. H., Holland P. V., Zimmerman H. J. Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure. N Engl J Med. 1976 Oct 21;295(17):909–913. doi: 10.1056/NEJM197610212951701. [DOI] [PubMed] [Google Scholar]
  3. Berquist K. R., Peterson J. M., Murphy B. L., Ebert J. W., Maynard J. E., Purcell R. H. Hepatitis B antigens in serum and liver of chimpanzees acutely infected with hepatitis B virus. Infect Immun. 1975 Sep;12(3):602–605. doi: 10.1128/iai.12.3.602-605.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eleftheriou N., Thomas H. C., Heathcote J., Sherlock S. Incidence and clinical significance of e antigen and antibody in acute and chronic liver disease. Lancet. 1975 Dec 13;2(7946):1171–1173. doi: 10.1016/s0140-6736(75)92657-4. [DOI] [PubMed] [Google Scholar]
  5. Hindman S. H., Gravelle C. R., Murphy B. L., Bradley D. W., Budge W. R., Maynard J. E. "e" Antigen, Dane particles, and serum DNA polymerase activity in HBsAg carriers. Ann Intern Med. 1976 Oct;85(4):458–460. doi: 10.7326/0003-4819-85-4-458. [DOI] [PubMed] [Google Scholar]
  6. Magnius L. O. Characterization of a new antigen-antibody system associated with hepatitis B. Clin Exp Immunol. 1975 May;20(2):209–216. [PMC free article] [PubMed] [Google Scholar]
  7. Magnius L. O., Espmark J. A. New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants. J Immunol. 1972 Nov;109(5):1017–1021. [PubMed] [Google Scholar]
  8. McAuliffe V. J., Purcell R. H., Le Bouvier G. L. Editorial: e: a third hepatitis B antigen? N Engl J Med. 1976 Apr 1;294(14):779–780. doi: 10.1056/NEJM197604012941411. [DOI] [PubMed] [Google Scholar]
  9. Mushahwar I. K., Overby L. R., Frosner G., Deinhardt F., Ling C. M. Prevalence of hepatitis B e antigen and its antibody as detected by radioimmunoassays. J Med Virol. 1978;2(2):77–87. doi: 10.1002/jmv.1890020202. [DOI] [PubMed] [Google Scholar]
  10. Neurath A. R., Strick N. Host specificity of a serum marker for hepatitis B: evidence that "e antigen" has the properties of an immunoglobulin. Proc Natl Acad Sci U S A. 1977 Apr;74(4):1702–1706. doi: 10.1073/pnas.74.4.1702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nielsen J. O., Dietrichson O., Juhl E. Incidence and meaning of the "e" determinant among hepatitis-B-antigen positive patients with acute and chronic liver diseases. Report from the Copenhagen Hepatitis Acuta Programme. Lancet. 1974 Oct 19;2(7886):913–915. doi: 10.1016/s0140-6736(74)91127-1. [DOI] [PubMed] [Google Scholar]
  12. Nordenfelt E., Kjellén L. Dane particles, DNA polymerase, and e-antigen in two different categories of hepatitis B antigen carriers. Intervirology. 1975;5(3-4):225–232. doi: 10.1159/000149918. [DOI] [PubMed] [Google Scholar]
  13. Shikata T., Karasawa T., Abe K., Uzawa T., Suzuki H., Oda T., Imai M., Mayumi M., Moritsugu Y. Hepatitis B e antigen and infectivity of hepatitis B virus. J Infect Dis. 1977 Oct;136(4):571–576. doi: 10.1093/infdis/136.4.571. [DOI] [PubMed] [Google Scholar]
  14. Tabor E., Gerety R. J., Barker L. F. Detection of e antigen during acute and chronic hepatitis B virus infections in chimpanzees. J Infect Dis. 1977 Oct;136(4):541–547. doi: 10.1093/infdis/136.4.541. [DOI] [PubMed] [Google Scholar]
  15. Takahashi K., Imai M., Tsuda F., Takahashi T., Miyakawa Y. Association of dane particles with e antigen in the serum of asymptomatic carriers of hepatitis B surface antigen. J Immunol. 1976 Jul;117(1):102–105. [PubMed] [Google Scholar]

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