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Mean age at pubertal onset by Tanner measure and birth cohort, for HIV-infected youth on combination antiretroviral treatment (cART, unshaded bars) as compared to those not on cART (non-cART, shaded bars) at the time of the first pubertal assessment. P-values for statistical significance based on interval-censored models for the effect of cART fit separately within each birth cohort.
