Figure 1. Results from quantifications of gene specific promoter methylation global methylation. (A) Scatter plot showing MetI values (mean methylation of the CpGs assessed in %) for each gene promoter in individual samples of SI-NETs. (B) Comparison of RASSF1A methylation in normal references, primary tumors and regional and distant metastases. (C) LINE1 global methylation in the different sample groups. Outliers are indicated by open circles and extremes by asterisks. P values for statistical comparisons between groups are indicated for suggestive P values ≤ 0.050 (*) or ≤ 0.01 (**), and for significant P-values ≤ 0.001 (***).