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. Author manuscript; available in PMC: 2014 Aug 26.
Published in final edited form as: Biosystems. 2008 Apr 4;92(3):270–281. doi: 10.1016/j.biosystems.2008.03.007

FIG. 1.

FIG. 1

Graphical representation of the system used as a case study to discuss multistability. The response component R is produced in a linear pathway, induced by an external stimulus S. The response component activates the enzyme E, which in turn facilitates the production of R through a positive feedback loop. This mechanism has been described as “mutual activation” (Tyson et al., 2003). The modification of the enzyme E follows a covalent reaction scheme (Goldbeter and Koshland Jr., 1981; Tyson et al., 2003).