Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1979 Jun;24(3):817–820. doi: 10.1128/iai.24.3.817-820.1979

Immunotherapy of guinea pig line 10 hepatoma with nonliving BCG cells in aqueous medium.

A Bekierkunst, M B Goren
PMCID: PMC414380  PMID: 381203

Abstract

Killed BCG cells suspended in 1.5% carboxymethylcellulose cured guinea pigs with established line 10 tumors in a high percentage of cases. The bacterial preparation of BCG in carboxymethylcellulose displayed a stronger tumor regressive activity and the process of healing was accelerated when endotoxin from a rough (Re) strain of Salmonella typhimurium was added to the BCG bacilli.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander P., Evans R. Endotoxin and double stranded RNA render macrophages cytotoxic. Nat New Biol. 1971 Jul 21;232(29):76–78. doi: 10.1038/newbio232076a0. [DOI] [PubMed] [Google Scholar]
  2. Bekierkunst A. Immunotherapy of cancer with nonliving mycobacteria and cord factor (trehalose-6,6'-dimycolate) in aqueous medium. J Natl Cancer Inst. 1976 Oct;57(4):963–964. doi: 10.1093/jnci/57.4.963. [DOI] [PubMed] [Google Scholar]
  3. Bekierkunst A., Levij I. S., Yarkoni E., Vilkas E., Lederer E. Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli. Infect Immun. 1971 Sep;4(3):245–255. doi: 10.1128/iai.4.3.245-255.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bekierkunst A., Wang L., Toubiana R., Lederer E. Immunotherapy of Cancer with Nonliving BCG and Fractions Derived from Mycobacteria: Role of Cord Factor (Trehalose-6, 6'-Dimycolate) in Tumor Regression. Infect Immun. 1974 Nov;10(5):1044–1050. doi: 10.1128/iai.10.5.1044-1050.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Carswell E. A., Old L. J., Kassel R. L., Green S., Fiore N., Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666–3670. doi: 10.1073/pnas.72.9.3666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chihara G., Hamuro J., Maeda Y., Arai Y., Fukuoka F. Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom). Cancer Res. 1970 Nov;30(11):2776–2781. [PubMed] [Google Scholar]
  7. Cluff L. E. Effects of endotoxins on susceptibility to infections. J Infect Dis. 1970 Sep;122(3):205–215. doi: 10.1093/infdis/122.3.205. [DOI] [PubMed] [Google Scholar]
  8. Cohen H. A., Bekierkunst A. Topical treatment of Kaposi's sarcoma, basal cell carcinoma and solar keratosis with ointment of BCG and cord factor. Dermatologica. 1979;158(2):117–125. doi: 10.1159/000250752. [DOI] [PubMed] [Google Scholar]
  9. Cohen H. A., Bekierkunst A. Treatment of mycosis fungoides with heat-killed BCG and cord factor. Dermatologica. 1979;158(2):104–116. doi: 10.1159/000250751. [DOI] [PubMed] [Google Scholar]
  10. Currie G. A., Basham C. Activated macrophages release a factor which lyses malignant cells but not normal cells. J Exp Med. 1975 Dec 1;142(6):1600–1605. doi: 10.1084/jem.142.6.1600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Dennert G., Tucker D. Antitumor polysaccharide lentinan. A T cell adjuvant. J Natl Cancer Inst. 1973 Nov;51(5):1727–1729. doi: 10.1093/jnci/51.5.1727. [DOI] [PubMed] [Google Scholar]
  12. Gery I., Gershon R. K., Waksman B. H. Potentiation of the T-lymphocyte response to mitogens. I. The responding cell. J Exp Med. 1972 Jul 1;136(1):128–142. doi: 10.1084/jem.136.1.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gery I., Waksman B. H. Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s). J Exp Med. 1972 Jul 1;136(1):143–155. doi: 10.1084/jem.136.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hunter J. T., Meltzer M. S., Ribi E., Fidler I. J., Hanna M. G., Jr, Zbar B., Rapp H. J. Glucan: attempts to demonstrate therapeutic activity against five syngeneic tumors in guinea pigs and mice. J Natl Cancer Inst. 1978 Feb;60(2):419–424. doi: 10.1093/jnci/60.2.419. [DOI] [PubMed] [Google Scholar]
  15. Mackaness G. B., Auclair D. J., Lagrange P. H. Immunopotentiation with BCG. I. Immune response to different strains and preparations. J Natl Cancer Inst. 1973 Nov;51(5):1655–1667. doi: 10.1093/jnci/51.5.1655. [DOI] [PubMed] [Google Scholar]
  16. Nowotny A. Molecular aspects of endotoxic reactions. Bacteriol Rev. 1969 Mar;33(1):72–98. doi: 10.1128/br.33.1.72-98.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Parr I., Wheeler E., Alexander P. Similarities of the anti-tumour actions of endotoxin, lipid A and double-stranded RNA. Br J Cancer. 1973 May;27(5):370–389. doi: 10.1038/bjc.1973.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rapp H. J., Churchill W. H., Jr, Kronman B. S., Rolley R. T., Hammond W. G., Borsos T. Antigenicity of a new diethylnitrosamine-induced transplantable guinea pig hepatoma: pathology and formation of ascites variant. J Natl Cancer Inst. 1968 Jul;41(1):1–7. [PubMed] [Google Scholar]
  19. Ribi E., Milner K. C., Granger D. L., Kelly M. T., Yamamoto K., Brehmer W., Parker R., Smith R. F., Strain S. M. Immunotherapy with nonviable microbial components. Ann N Y Acad Sci. 1976;277(00):228–238. doi: 10.1111/j.1749-6632.1976.tb41700.x. [DOI] [PubMed] [Google Scholar]
  20. Wilton J. M., Rosenstreich D. L., Oppenheim J. J. Activation of guinea pig macrophages by bacterial lipopolysaccharide requires bone marrow-derived lymphocytes. J Immunol. 1975 Jan;114(1 Pt 2):388–393. [PubMed] [Google Scholar]
  21. Yang C., Nowotny A. Effect of endotoxin on tumor resistance in mice. Infect Immun. 1974 Jan;9(1):95–100. doi: 10.1128/iai.9.1.95-100.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES