Abstract
Investigation of the inactivators of fibroblast interferon has shown that those substances could be identified in every specimen of serum taken from normal individuals. These inactivators were found to destroy a mean of 82% of the interferon antiviral activity beyond that caused by the effects of temperature alone. The inactivators exerted no effect at 4 degrees C but were found in a variety of animal as well as human sera. Although slight differences were found to exist in the extent of inactivation when comparing normal human serum to serum from patients (i) receiving chronic hemodialysis, (ii) with jaundice, or (iii) with underlying malignancies, the differences did not appear to be clinically significant. In exploring the nature of the substances, we found that both dialyzable and non-dialyzable inactivators exist, but the former appear to be the major factors responsible for the unwanted process.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cesario T. C., Mandell A., Tilles J. G. Inactivation of human interferon by body fluids. Proc Soc Exp Biol Med. 1973 Dec;144(3):1030–1032. doi: 10.3181/00379727-144-37735. [DOI] [PubMed] [Google Scholar]
- Cesario T. C., Schryer P. J., Tilles J. G. Relationship between the physicochemical nature of human interferon, the cell induced, and the inducing agent. Antimicrob Agents Chemother. 1977 Feb;11(2):291–298. doi: 10.1128/aac.11.2.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cesario T. C. The effect of body fluids on polynucleotide-induced fibroblast interferon and virus-induced leukocyte interferon. Proc Soc Exp Biol Med. 1977 Sep;155(4):583–587. doi: 10.3181/00379727-155-39855. [DOI] [PubMed] [Google Scholar]
- Cesario T., Tilles J. G. Inactivation of human interferon by urine. J Infect Dis. 1973 Mar;127(3):311–314. doi: 10.1093/infdis/127.3.311. [DOI] [PubMed] [Google Scholar]
- Cheeseman S. H., Rinaldo C. R., Jr, Hirsch M. S. Use of interferon in cytomegalovirus infections in man. Tex Rep Biol Med. 1977;35:523–527. [PubMed] [Google Scholar]
- Desmyter J. The use of interferon in viral hepatitis B. Tex Rep Biol Med. 1977;35:516–522. [PubMed] [Google Scholar]
- Tilles J. G., Finland M. Microassay for human and chick cell interferons. Appl Microbiol. 1968 Nov;16(11):1706–1707. doi: 10.1128/am.16.11.1706-1707.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]