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. 1995 Jul 18;92(15):6906–6910. doi: 10.1073/pnas.92.15.6906

Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner.

P van Gelderen 1, N F Ramsey 1, G Liu 1, J H Duyn 1, J A Frank 1, D R Weinberger 1, C T Moonen 1
PMCID: PMC41439  PMID: 7624341

Abstract

Functional magnetic resonance imaging (fMRI) is a tool for mapping brain function that utilizes neuronal activity-induced changes in blood oxygenation. An efficient three-dimensional fMRI method is presented for imaging brain activity on conventional, widely available, 1.5-T scanners, without additional hardware. This approach uses large magnetic susceptibility weighting based on the echo-shifting principle combined with multiple gradient echoes per excitation. Motor stimulation, induced by self-paced finger tapping, reliably produced significant signal increase in the hand region of the contralateral primary motor cortex in every subject tested.

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Selected References

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