Abstract
A form of systemic tetanus with atypical symptoms was observed in mice injected in the left thigh with a mixture of tetanus toxin and antibody produced in guinea pigs against a fragment of toxin obtained from a subtilisin digest of the crystallized toxin. The mice did not show typical symptoms of the local tetanus such as convulsions or spastic paralysis of the injected limb.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Helting T. B., Ronneberger H. J., Vollerthun R., Neubauer V. Toxicity of papain-digested tetanus toxin. Pathological effect of fragment B in the absence of spastic paralysis. J Biol Chem. 1978 Jan 10;253(1):125–129. [PubMed] [Google Scholar]
- Helting T. B., Zwisler O. Structure of tetanus toxin. I. Breakdown of the toxin molecule and discrimination between polypeptide fragments. J Biol Chem. 1977 Jan 10;252(1):187–193. [PubMed] [Google Scholar]
- Helting T. B., Zwisler O., Wiegandt H. Structure of tetanus toxin. II. Toxin binding to ganglioside. J Biol Chem. 1977 Jan 10;252(1):194–198. [PubMed] [Google Scholar]
- Matsuda M., Yoneda M. Antigenic substructure of tetanus neurotoxin. Biochem Biophys Res Commun. 1977 Jul 11;77(1):268–274. doi: 10.1016/s0006-291x(77)80192-7. [DOI] [PubMed] [Google Scholar]
- Matsuda M., Yoneda M. Isolation and purification of two antigenically active, "complimentary" polypeptide fragments of tetanus neurotoxin. Infect Immun. 1975 Nov;12(5):1147–1153. doi: 10.1128/iai.12.5.1147-1153.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mellanby J., Mellanby H., Pope D., Van Heyningen W. E. Ganglioside as a prophylactic agent in experimental tetanus in mice. J Gen Microbiol. 1968 Dec;54(2):161–168. doi: 10.1099/00221287-54-2-161. [DOI] [PubMed] [Google Scholar]
- Nagel J., Cohen H. Studies on tetanus antitoxins. II. Demonstration of at least four antitoxins of different specificity in antitoxic sera. J Immunol. 1973 May;110(5):1388–1395. [PubMed] [Google Scholar]