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. 1979 Aug;25(2):771–773. doi: 10.1128/iai.25.2.771-773.1979

Liposomal enhancement of the immunogenicity of adenovirus type 5 hexon and fiber vaccines.

W J Kramp, H R Six, S Drake, J A Kasel
PMCID: PMC414511  PMID: 489132

Abstract

Immunogenicity of adenovirus capsid proteins carried in liposomes was comparable to that with equivalent doses administered in Freund adjuvant, and both forms were more potent than aqueous vaccines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams D. H., Joyce G., Richardson V. J., Ryman B. E., Wiśniewski H. M. Liposome toxicity in the mouse central nervous system. J Neurol Sci. 1977 Mar;31(2):173–179. doi: 10.1016/0022-510x(77)90104-6. [DOI] [PubMed] [Google Scholar]
  2. Allison A. G., Gregoriadis G. Liposomes as immunological adjuvants. Nature. 1974 Nov 15;252(5480):252–252. doi: 10.1038/252252a0. [DOI] [PubMed] [Google Scholar]
  3. Couch R. B., Kasel J. A., Perreira H. G., Haase A. T., Knight V. Induction of immunity in man by crystalline adenovirus type 5 capsid antigens. Proc Soc Exp Biol Med. 1973 Sep;143(4):905–910. doi: 10.3181/00379727-143-37438. [DOI] [PubMed] [Google Scholar]
  4. Haase A. T., Pereira H. G. The purification of adenovirus neutralizing antibody: adenovirus type 5 hexon immunoadsorbent. J Immunol. 1972 Mar;108(3):633–636. [PubMed] [Google Scholar]
  5. Heath T. D., Edwards D. C., Ryman B. E. The adjuvant properties of liposomes. Biochem Soc Trans. 1976;4(1):129–133. doi: 10.1042/bst0040129. [DOI] [PubMed] [Google Scholar]
  6. KASEL J. A., HUBER M., LODA F., BANKS P. A., KNIGHT V. IMMUNIZATION OF VOLUNTEERS WITH SOLUBLE ANTIGENS OF ADENOVIRUS TYPE 1. Proc Soc Exp Biol Med. 1964 Oct;117:186–190. doi: 10.3181/00379727-117-29531. [DOI] [PubMed] [Google Scholar]
  7. Kataoka T., Williamson J. R., Kinsky S. C. Release of macromolecular markers (enzymes) from liposomes treated with antibody and complement. An attempt at correlation with electron microscopic observations. Biochim Biophys Acta. 1973 Mar 16;298(2):158–179. doi: 10.1016/0005-2736(73)90347-7. [DOI] [PubMed] [Google Scholar]
  8. Kinsky S. C. Immunogenicity of liposomal model membranes. Ann N Y Acad Sci. 1978;308:111–123. doi: 10.1111/j.1749-6632.1978.tb22017.x. [DOI] [PubMed] [Google Scholar]
  9. Kinsky S. C. Preparation of liposomes and a spectrophotometric assay for release of trapped glucose marker. Methods Enzymol. 1974;32:501–513. doi: 10.1016/0076-6879(74)32050-2. [DOI] [PubMed] [Google Scholar]
  10. Mautner V., Pereira H. G. Crystallization of a second adenovirus protein (the fibre). Nature. 1971 Apr 16;230(5294):456–457. doi: 10.1038/230456a0. [DOI] [PubMed] [Google Scholar]
  11. Pereira H. G., Valentine R. C., Russell W. C. Crystallization of an adenovirus protein (the hexon). Nature. 1968 Aug 31;219(5157):946–947. doi: 10.1038/219946a0. [DOI] [PubMed] [Google Scholar]
  12. Sessa G., Weissmann G. Incorporation of lysozyme into liposomes. A model for structure-linked latency. J Biol Chem. 1970 Jul 10;245(13):3295–3301. [PubMed] [Google Scholar]
  13. Siddiqui W. A., Taylor D. W., Kan S. C., Kramer K., Richmond-Crum S. M., Kotani S., Shiba T., Kusumoto S. Vaccination of experimental monkeys against Plasmodium falciparum: a possible safe adjuvant. Science. 1978 Sep 29;201(4362):1237–1239. doi: 10.1126/science.99814. [DOI] [PubMed] [Google Scholar]
  14. Six H. R., Young W. W., Jr, Uemura K., Kinsky S. C. Effect of antibody-complement on multiple vs. single compartment liposomes. Application of a fluorometric assay for following changes in liposomal permeability. Biochemistry. 1974 Sep 10;13(19):4050–4058. doi: 10.1021/bi00716a037. [DOI] [PubMed] [Google Scholar]
  15. Udenfriend S., Stein S., Böhlen P., Dairman W., Leimgruber W., Weigele M. Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range. Science. 1972 Nov 24;178(4063):871–872. doi: 10.1126/science.178.4063.871. [DOI] [PubMed] [Google Scholar]
  16. WILCOX W. C., GINSBERG H. S. PRODUCTION OF SPECIFIC NEUTRALIZING ANTIBODY WITH SOLUBLE ANTIGENS OF TYPE 5 ADENOVIRUS. Proc Soc Exp Biol Med. 1963 Oct;114:37–42. doi: 10.3181/00379727-114-28579. [DOI] [PubMed] [Google Scholar]
  17. Willcox N., Mautner V. Antigenic determinants of adenovirus capsids. I. Measurement of antibody cross-reactivity. J Immunol. 1976 Jan;116(1):19–24. [PubMed] [Google Scholar]

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