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. 1979 Sep;25(3):786–791. doi: 10.1128/iai.25.3.786-791.1979

Diphtheria toxin-binding glycoproteins on hamster cells: candidates for diphtheria toxin receptors.

R L Proia, L Eidels, D A Hart
PMCID: PMC414516  PMID: 315374

Abstract

Diphtheria toxin-binding glycoproteins of high molecular weight (greater than 100,000) were identified on the surface of lymph node and thymus cells from hamsters, a diphtheria toxin-sensitive species. These diphtheria toxin-binding glycoproteins also interacted with CRM197 protein, which possesses toxin-blocking activity, but not with diphtheria toxoid, fragment A of diphtheria toxin, or cholera toxin, all of which lack toxin-blocking activity. These observations are consistent with the hypothesis that the detected diphtheria toxin-binding glycoproteins are involved in intoxication of cells by this toxin and possibly serve as the plasma membrane receptors for diphtheria toxin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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