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Infection and Immunity logoLink to Infection and Immunity
. 1979 Sep;25(3):828–830. doi: 10.1128/iai.25.3.828-830.1979

Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis.

H L Walker, C G McLeod Jr, S H Leppla, A D Mason Jr
PMCID: PMC414522  PMID: 500188

Abstract

The search for methods to achieve control of Pseudomonas aeruginosa infection continues with the introduction of aluminum-absorbed toxoid developed from P. aeruginosa exotoxin. This toxoid induces significant titers of neutralizing and precipitating antibodies for toxin A when given with appropriate adjuvants. These experiments show that immunization with aluminum phosphate-absorbed toxoid failed to protect burned rats infected with P. aeruginosa. These and previous experiments show that active immunization with live P. aeruginosa provides good strain-specific protection in the same model. No cross-protection was demonstrated between strains of P. aeruginosa in these experiments.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buhles W. C., Jr, Shifrine M. Adjuvant protection against bacterial infection in granulocytopenic mice. J Infect Dis. 1977 Jul;136(1):90–95. doi: 10.1093/infdis/136.1.90. [DOI] [PubMed] [Google Scholar]
  2. Iglewski B. H., Liu P. V., Kabat D. Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo. Infect Immun. 1977 Jan;15(1):138–144. doi: 10.1128/iai.15.1.138-144.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Leppla S. H. Large-scale purification and characterization of the exotoxin of Pseudomonas aeruginosa. Infect Immun. 1976 Oct;14(4):1077–1086. doi: 10.1128/iai.14.4.1077-1086.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Liu P. V. The roles of various fractions of Pseudomonas aeruginosa in its pathogenesis. 3. Identity of the lethal toxins produced in vitro and in vivo. J Infect Dis. 1966 Oct;116(4):481–489. doi: 10.1093/infdis/116.4.481. [DOI] [PubMed] [Google Scholar]
  5. Pavlovskis O. R., Pollack M., Callahan L. T., 3rd, Iglewski B. H. Passive protection by antitoxin in experimental Pseudomonas aeruginosa burn infections. Infect Immun. 1977 Dec;18(3):596–602. doi: 10.1128/iai.18.3.596-602.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Pollack M., Taylor N. S., Callahan L. T., 3rd Exotoxin production by clinical isolates of pseudomonas aeruginosa. Infect Immun. 1977 Mar;15(3):776–780. doi: 10.1128/iai.15.3.776-780.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Saelinger C. B., Snell K., Holder I. A. Experimental studies on the pathogenesis of infections due to Pseudomonas aeruginosa: direct evidence for toxin production during Pseudomonas infection of burned skin tissues. J Infect Dis. 1977 Oct;136(4):555–561. doi: 10.1093/infdis/136.4.555. [DOI] [PubMed] [Google Scholar]
  8. Snell K., Holder I. A., Leppla S. A., Saelinger C. B. Role of exotoxin and protease as possible virulence factors in experimental infections with Pseudomonas aeruginosa. Infect Immun. 1978 Mar;19(3):839–845. doi: 10.1128/iai.19.3.839-845.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Stieritz D. D., Holder I. A. Experimental studies of the pathogenesis of Pseudomonas aeruginosa infection: evidence for the in-vivo production of a lethal toxin. J Med Microbiol. 1978 May;11(2):101–109. doi: 10.1099/00222615-11-2-101. [DOI] [PubMed] [Google Scholar]
  10. WALKER H. L., MASON A. D., Jr, RAULSTON G. L. SURFACE INFECTION WITH PSEUDOMONAS AERUGINOSA. Ann Surg. 1964 Aug;160:297–305. doi: 10.1097/00000658-196408000-00019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Walker H. L., Mason A. D., Jr A standard animal burn. J Trauma. 1968 Nov;8(6):1049–1051. doi: 10.1097/00005373-196811000-00006. [DOI] [PubMed] [Google Scholar]

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