Abstract
The cell surface antigens of Escherichia coli B were investigated. We found that mice immunized with live bacteria responded with an immune response directed mainly against the protein structure of the cell surface. The lipopolysaccharide component of the bacterium was immunogenic, but its contribution to the overall response was only secondary. It is suggested that when considering the immune response to gram-negative bacteria, more attention should be given to the protein antigens.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barber C., Eylan E., Keydar J. Sur les déterminants communs des Enterobacteriaceae. Pathol Microbiol (Basel) 1968;31(6):321–327. [PubMed] [Google Scholar]
- Danneman P. J., Michael J. G. Reaginic antibody production to protein antigens of Escherichia coli and Pseudomonas aeruginosa by mice. Infect Immun. 1976 Sep;14(3):694–702. doi: 10.1128/iai.14.3.694-702.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kaijser B. Immunological studies of an antigen common to many gram-negative bacteria with special reference to E. coli. Characterization and biological significance. Int Arch Allergy Appl Immunol. 1975;48(1):72–81. doi: 10.1159/000231293. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Michael J. G. The surface antigens and phage receptors in Escherichia coli B. Proc Soc Exp Biol Med. 1968 Jun;128(2):434–438. doi: 10.3181/00379727-128-33031. [DOI] [PubMed] [Google Scholar]
- Pusztai A. The properties of bovine serum albumin and chymotrypsinogen A in solvent mixtures containing phenol. Biochem J. 1966 Nov;101(2):265–273. doi: 10.1042/bj1010265. [DOI] [PMC free article] [PubMed] [Google Scholar]