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. Author manuscript; available in PMC: 2014 Aug 27.
Published in final edited form as: Chembiochem. 2011 Jun 10;12(11):1749–1758. doi: 10.1002/cbic.201100123

Figure 2. Analysis of remodeling pathways used by diverse polyphenolic glycosides and aglycones to inactivate Aβ42 soluble oligomers.

Figure 2

Aβ soluble oligomers (25 μM) were incubated with each small molecule shown in (A) for 4 h, and analyzed using (B) dot blots probed with conformation-specific (A11, soluble oligomer) and sequence-specific (6E10) antibodies, (C) PC12 cell toxicity assay (n=3), (D) AFM, and (E) ANS fluorescence. In (D), soluble oligomers were incubated with the vehicle (1% DMSO) or 200 μM compound, and each image is 3 × 3 μm or (inset is 0.5 × 0.5 μm).