Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1979 Sep;25(3):998–1002. doi: 10.1128/iai.25.3.998-1002.1979

Reactivation of polyoma virus in kidneys of persistently infected mice during pregnancy.

D J McCance, C A Mims
PMCID: PMC414547  PMID: 227790

Abstract

Female mice infected at birth with 10(7) 50% tissue culture infective doses of polyoma virus were mated when at least 6 weeks old. Polyoma was not detected in any tissues of 27 female mice before mating except for trace amounts in the kidneys of 2 mice, but late in gestation polyoma virus could be found in the kidneys of 21 of 38 mice with titers of 10(3.7) to 10(6.2) 50% tissue culture infective doses per gram of kidney. The virus was not detected in the brain, salivary gland, lung, liver, spleen, ovaries, placenta, or fetuses during gestation. Nonpregnant females were injected with female sex hormones over a period of 17 days, and polyoma was then detected in kidneys of 4 of 18 mice. Treatment of cultures of mouse embryo fibroblasts with either sexhormones or a glucocorticosteroid resulted in approximately a threefold increase in the rate of infection of cells with polyoma virus.

Full text

PDF

Images in this article

1000Image
on p.1000

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barlow S. M., Morrison P. J., Sullivan F. M. Plasma corticosterone levels during pregnancy in the mouse: the relative contributions of the adrenal glands and foeto-placental units. J Endocrinol. 1974 Mar;60(3):473–483. doi: 10.1677/joe.0.0600473. [DOI] [PubMed] [Google Scholar]
  2. Birkeland S. A., Kristoffersen K. Cellular immunity in pregnancy: blast transformation and rosette formation of maternal T and B lymphocytes: A cross-section analysis. Clin Exp Immunol. 1977 Dec;30(3):408–412. [PMC free article] [PubMed] [Google Scholar]
  3. CAIRNS J. The initiation of vaccinia infection. Virology. 1960 Jul;11:603–623. doi: 10.1016/0042-6822(60)90103-3. [DOI] [PubMed] [Google Scholar]
  4. Choi Y. C., Hsiung G. D. Cytomegalovirus infection in guinea pigs. II. Transplacental and horizontal transmission. J Infect Dis. 1978 Aug;138(2):197–202. doi: 10.1093/infdis/138.2.197. [DOI] [PubMed] [Google Scholar]
  5. Coleman D. V., Daniel R. A., Gardner S. D., Field A. M., Gibson P. E. Polyoma virus in urine during pregnancy. Lancet. 1977 Oct 1;2(8040):709–710. doi: 10.1016/s0140-6736(77)90514-1. [DOI] [PubMed] [Google Scholar]
  6. Giron D. J., Allen P. T. Effect of Estrogen and Other Steroids on MM Virus Infection in Mice. Infect Immun. 1970 Oct;2(4):426–430. doi: 10.1128/iai.2.4.426-430.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McCance D. J., Mims C. A. Transplacental transmission of polyoma virus in mice. Infect Immun. 1977 Oct;18(1):196–202. doi: 10.1128/iai.18.1.196-202.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McCormack J. T., Greenwald G. S. Progesterone and oestradiol-17beta concentrations in the peripheral plasma during pregnancy in the mouse. J Endocrinol. 1974 Jul;62(1):101–107. doi: 10.1677/joe.0.0620101. [DOI] [PubMed] [Google Scholar]
  9. Petrucco O. M., Seamark R. F., Holmes K., Forbes I. J., Symons R. G. Changes in lymphocyte function during pregnancy. Br J Obstet Gynaecol. 1976 Mar;83(3):245–250. doi: 10.1111/j.1471-0528.1976.tb00818.x. [DOI] [PubMed] [Google Scholar]
  10. ROWE W. P., HARTLEY J. W., ESTES J. D., HUEBNER R. J. Growth curves of polyoma virus in mice and hamsters. Natl Cancer Inst Monogr. 1960 Sep;4:189–209. [PubMed] [Google Scholar]
  11. Ringold G. M., Shank P. R., Yamamoto K. R. Production of unintegrated mouse mammary tumor virus DNA in infected rat hepatoma cells is a secondary action of dexamethasone. J Virol. 1978 Apr;26(1):93–101. doi: 10.1128/jvi.26.1.93-101.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rosenstreich D. L., Glode L. M. Difference in B cell mitogen responsiveness between closely related strains of mice. J Immunol. 1975 Sep;115(3):777–780. [PubMed] [Google Scholar]
  13. Rziha H. J., Bornkamm G. W., zur Hausen H. BK virus: I. Seroepidemiologic studies and serologic response to viral infection. Med Microbiol Immunol. 1978 Jul 4;165(2):73–81. doi: 10.1007/BF02122742. [DOI] [PubMed] [Google Scholar]
  14. Scolnick E. M., Young H. A., Parks W. P. Biochemical and physiological mechanisms in glucocorticoid hormone induction of mouse mammary tumor virus. Virology. 1976 Jan;69(1):148–156. doi: 10.1016/0042-6822(76)90202-6. [DOI] [PubMed] [Google Scholar]
  15. Shah K. V., Rangan S. R., Reissig M., Daniel R. W., Bellhan F. Z. Congenital transmission of a papovavirus of the stump-tailed macaque. Science. 1977 Jan 28;195(4276):404–406. doi: 10.1126/science.401546. [DOI] [PubMed] [Google Scholar]
  16. Thong Y. H., Steele R. W., Vincent M. M., Hensen S. A., Bellanti J. A. Impaired in vitro cell-mediated immunity to rubella virus during pregnancy. N Engl J Med. 1973 Sep 20;289(12):604–606. doi: 10.1056/NEJM197309202891203. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES