Abstract
Group A streptococcal pyrogenic exotoxins types A, B, and C and staphylococcal pyrogenic exotoxin were shown to be potent nonspecific T-lymphocyte mitogens. Adherent cell populations did not significantly affect the nonspecific mitogenicity.
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Selected References
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- Barsumian E. L., Cunningham C. M., Schlievert P. M., Watson D. W. Heterogeneity of group A streptococcal pyrogenic exotoxin type B. Infect Immun. 1978 May;20(2):512–518. doi: 10.1128/iai.20.2.512-518.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barsumian E. L., Schlievert P. M., Watson D. W. Nonspecific and specific immunological mitogenicity by group A streptococcal pyrogenic exotoxins. Infect Immun. 1978 Dec;22(3):681–688. doi: 10.1128/iai.22.3.681-688.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown J. M., Leon M. A., Lightbody J. J. Isolation of a human lymphocyte mitogen from wheat germ with N-acetyl-D-glucosamine specificity. J Immunol. 1976 Nov;117(5 PT2):1976–1980. [PubMed] [Google Scholar]
- Chisari F. V., Northrup R. S., Chen L. C. The modulating effect of cholera enterotoxin on the immune response. J Immunol. 1974 Sep;113(3):729–739. [PubMed] [Google Scholar]
- Cunningham C. M., Watson D. W. Alteration of clearance function by group A streptococcal pyrogenic exotoxin and its relation to suppression of the antibody response. Infect Immun. 1978 Jan;19(1):51–57. doi: 10.1128/iai.19.1.51-57.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cunningham C. M., Watson D. W. Suppression of antibody response by group A streptococcal pyrogenic exotoxin and characterization of the cells involved. Infect Immun. 1978 Feb;19(2):470–476. doi: 10.1128/iai.19.2.470-476.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HANNA E. E., WATSON D. W. HOST-PARASITE RELATIONSHIPS AMONG GROUP A STREPTOCOCCI. 3. DEPRESSION OF RETICULOENDOTHELIAL FUNCTION BY STREPTOCOCCAL PYROGENIC EXOTOXINS. J Bacteriol. 1965 Jan;89:154–158. doi: 10.1128/jb.89.1.154-158.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hale M. L., Hanna E. E. Deregulation of mouse antibody-forming cells by streptococcal pyrogenic exotoxin. II. Modification of spleen T-cell-complemented nude mouse PFC responses. Cell Immunol. 1976 Oct;26(2):168–177. doi: 10.1016/0008-8749(76)90361-0. [DOI] [PubMed] [Google Scholar]
- Hanna E. E., Watson D. W. Enhanced immune response after immunosuppression by Streptococcal pyrogenic exotoxin. Infect Immun. 1973 Jun;7(6):1009–1011. doi: 10.1128/iai.7.6.1009-1011.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hart D. A., Finkelstein R. A. Inhibition of mitogen stimulation of human peripheral blood leukocytes by Vibrio cholerae enterotoxin. J Immunol. 1975 Jan;114(1 Pt 2):476–480. [PubMed] [Google Scholar]
- Kaplan J. Staphylococcal enterotoxin B induced release of macrophage migration inhibition factor from normal lymphocytes. Cell Immunol. 1972 Feb;3(2):245–252. doi: 10.1016/0008-8749(72)90163-3. [DOI] [PubMed] [Google Scholar]
- Kim Y. B., Watson D. W. A purified group A streptococcal pyrogenic exotoxin. Physiochemical and biological properties including the enhancement of susceptibility to endotoxin lethal shock. J Exp Med. 1970 Mar 1;131(3):611–622. doi: 10.1084/jem.131.3.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ly I. A., Mishell R. I. Separation of mouse spleen cells by passage through columns of sephadex G-10. J Immunol Methods. 1974 Aug;5(3):239–247. doi: 10.1016/0022-1759(74)90108-2. [DOI] [PubMed] [Google Scholar]
- Mosier D. E. A requirement for two cell types for antibody formation in vitro. Science. 1967 Dec 22;158(3808):1573–1575. doi: 10.1126/science.158.3808.1573. [DOI] [PubMed] [Google Scholar]
- Rosenstreich D. L., Farrar J. J., Dougherty S. Absolute macrophage dependency of T lymphocyte activation by mitogens. J Immunol. 1976 Jan;116(1):131–139. [PubMed] [Google Scholar]
- Schlievert P. M., Bettin K. M., Watson D. W. Purification and characterization of group A streptococcal pyrogenic exotoxin type C. Infect Immun. 1977 May;16(2):673–679. doi: 10.1128/iai.16.2.673-679.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schlievert P. M., Schoettle D. J., Watson D. W. Purification and physicochemical and biological characterization of a staphylococcal pyrogenic exotoxin. Infect Immun. 1979 Mar;23(3):609–617. doi: 10.1128/iai.23.3.609-617.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith B. G., Johnson H. M. The effect of staphylococcal enterotoxins on the primary in vitro immune response. J Immunol. 1975 Aug;115(2):575–578. [PubMed] [Google Scholar]
- WATSON D. W. Host-parasite factors in group A streptococcal infections. Pyrogenic and other effects of immunologic distinct exotoxins related to scarlet fever toxins. J Exp Med. 1960 Feb 1;111:255–284. doi: 10.1084/jem.111.2.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Warren J. R., Leatherman D. L., Metzger J. F. Evidence for cell-receptor activity in lymphocyte stimulation by staphylococcal enterotoxin. J Immunol. 1975 Jul;115(1):49–53. [PubMed] [Google Scholar]
- Yam L. T., Li C. Y., Crosby W. H. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971 Mar;55(3):283–290. doi: 10.1093/ajcp/55.3.283. [DOI] [PubMed] [Google Scholar]